meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione

Base Information

• Chemical Name: meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione
• CAS No.: 1551326-21-6
• Molecular Formula: C₂₈H₃₈O₈
• Molecular Weight: 502.605
• Mol file: 1551326-21-6.mol

Synonyms:

Chemical Property of meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione

There total 2 articles about meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

4-(3,4,6-trimethoxy-2-methylphenyl)but-3-yn-2-one → 3,4-dimethyl-1,6-bis(3,4,6-trimethoxy-2-methylphenyl)hexa-1,5-diene-3,4-diol + meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione (1551326-21-6)

Guidance literature:

With zinc/copper couple; acetic acid; In tetrahydrofuran; for 30h;

DOI:10.1039/c3ob42333f

Reference yield:

4-(3,4,6-trimethoxy-2-methylphenyl)but-3-yn-2-ol (1551325-18-8) → 3,4-dimethyl-1,6-bis(3,4,6-trimethoxy-2-methylphenyl)hexa-1,5-diene-3,4-diol + meso-4,5-bis(3,4,6-trimethoxy-2-methylphenyl)octane-2,7-dione (1551326-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride; dimethyl sulfoxide / dichloromethane / 24 h / Inert atmosphere

2: acetic acid; zinc/copper couple / tetrahydrofuran / 30 h

With zinc/copper couple; acetic anhydride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3ob42333f

upstream raw materials:

4-(3,4,6-trimethoxy-2-methylphenyl)but-3-yn-2-ol