C₄₄H₄₃ClF₃NNiO₃P₂

Base Information

• Chemical Name: C₄₄H₄₃ClF₃NNiO₃P₂
• CAS No.: 1426252-13-2
• Molecular Formula: C₄₄H₄₃ClF₃NNiO₃P₂
• Molecular Weight: 846.916
• Mol file: 1426252-13-2.mol

Synonyms:

Chemical Property of C₄₄H₄₃ClF₃NNiO₃P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₄₃ClF₃NNiO₃P₂

There total 7 articles about C₄₄H₄₃ClF₃NNiO₃P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Dimethylaminophenol (99-07-0) → C44H43ClF3NNiO3P2 (1426252-13-2)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate / acetone / 96 h / Reflux

2: N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere

3: toluene / 20 °C / Glovebox

4: tetrahydrofuran / 2 h / 20 °C / Glovebox

5: tetrahydrofuran / 0 °C / Inert atmosphere; Glovebox; Sealed tube

With N-Bromosuccinimide; caesium carbonate; In tetrahydrofuran; dichloromethane; acetone; toluene;

DOI:10.1039/c2dt32735j

Reference yield:

1-bromo-2,5-dimethoxybenzene (25245-34-5) → C44H43ClF3NNiO3P2 (1426252-13-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; dihydrogen peroxide / chloroform; water / 20 °C

2: isopropylmagnesium chloride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

3: tetrahydrofuran / 0 °C / Inert atmosphere; Glovebox; Sealed tube

With hydrogenchloride; dihydrogen peroxide; isopropylmagnesium chloride; In tetrahydrofuran; chloroform; water; 2: |Grignard Reaction;

DOI:10.1039/c2dt32735j

Reference yield:

N,N-dimethyl-3-(2,2,2-trifluoroethoxy)aniline (66799-74-4) → C44H43ClF3NNiO3P2 (1426252-13-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere

2: toluene / 20 °C / Glovebox

3: tetrahydrofuran / 2 h / 20 °C / Glovebox

4: tetrahydrofuran / 0 °C / Inert atmosphere; Glovebox; Sealed tube

With N-Bromosuccinimide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1039/c2dt32735j

upstream raw materials:

C₃₆H₃₅BrF₃NNiOP₂

C₈H₈Cl₂MgO₂

3-Dimethylaminophenol

1-bromo-2,5-dimethoxybenzene

Downstream raw materials:

1,2-bis(diphenylphosphino)ethane-bis(triphenylphosphine)nickel⁽⁰⁾

C₁₈H₁₉ClF₃NO₃