C₄₉H₅₂N₂O₂₂

Base Information

• Chemical Name: C₄₉H₅₂N₂O₂₂
• CAS No.: 168073-11-8
• Molecular Formula: C₄₉H₅₂N₂O₂₂
• Molecular Weight: 1020.95
• Mol file: 168073-11-8.mol

Synonyms:

Chemical Property of C₄₉H₅₂N₂O₂₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₅₂N₂O₂₂

There total 8 articles about C₄₉H₅₂N₂O₂₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate (72692-06-9,73464-50-3,3082-95-9) → C49H52N2O22 (168073-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / toluene / 65 °C

2: CF₃COOH / CH₂Cl₂

3: 1.) BOP-Cl, EtN(i-Pr)2; 2.) EtN(i-Pr)2 / 1.) CH₂Cl₂; 2.) CH₂Cl₂

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1016/0040-4039(95)00049-I

Reference yield:

homophthalic anhydride (703-59-3) → C49H52N2O22 (168073-11-8)

Guidance literature:

Multi-step reaction with 7 steps

1: DMAP

2: H₂SO₄ / CH₂Cl₂

3: Pd(PPh₃)4, morpholine / tetrahydrofuran

4: (PhO)2P(O)N₃, Et₃N / toluene / 65 °C

5: Et₃N / toluene / 65 °C

6: CF₃COOH / CH₂Cl₂

7: 1.) BOP-Cl, EtN(i-Pr)2; 2.) EtN(i-Pr)2 / 1.) CH₂Cl₂; 2.) CH₂Cl₂

With morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; diphenyl phosphoryl azide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/0040-4039(95)00049-I

Reference yield:

2-Carboxymethyl-benzoic acid tert-butyl ester (168072-81-9) → C49H52N2O22 (168073-11-8)

Guidance literature:

Multi-step reaction with 4 steps

1: (PhO)2P(O)N₃, Et₃N / toluene / 65 °C

2: Et₃N / toluene / 65 °C

3: CF₃COOH / CH₂Cl₂

4: 1.) BOP-Cl, EtN(i-Pr)2; 2.) EtN(i-Pr)2 / 1.) CH₂Cl₂; 2.) CH₂Cl₂

With diphenyl phosphoryl azide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1016/0040-4039(95)00049-I

upstream raw materials:

daunomycin hydrochloride

(2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(2-carboxy-benzylcarbamoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate

homophthalic anhydride

Downstream raw materials:

C₄₂H₄₄N₂O₁₉