3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

Base Information

Chemical Name:3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester
CAS No.:412297-84-8
Molecular Formula:C₂₀H₂₃NO₆
Molecular Weight:373.406
Hs Code.:

Synonyms:

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Chemical Property of 3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

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Technology Process of 3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

There total 1 articles about 3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56294-09-8
ethyl 5-methoxycarbonyl-3-oxopentanoate

: 412297-84-8
3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

Guidance literature:: With acetic acid; sodium nitrite; anschliessend Erwaermen mit Acetessigsaeure-benzylester, Natriumacetat, Zink-Pulver und Essigsaeure;
DOI:10.1039/jr9520004176

Reference yield: 12.0%

: 412297-84-8
3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 4-(benzylmethanoate)-3[(methoxycarbonyl)ethyl]-5-methylpyrrole-2-carboxaldehyde

Guidance literature:: 3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester; With potassium hydroxide; In ethylene glycol; for 4h; Reflux;

With sulfuric acid; In methanol; for 3h; Reflux;

N,N-dimethyl-formamide; With trichlorophosphate; In dichloromethane; at 0 ℃; for 2.25h; Reflux;
DOI:10.1039/c7ra01628j

Reference yield:

: 412297-84-8
3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

: (Z)-benzyl 4-(2-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)methyl)-3-(3-methoxy-3-oxopropyl)-5-methyl-1H-pyrrol-3-yl)formate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethylene glycol / 4 h / Reflux

1.2: 3 h / Reflux

1.3: 2.25 h / 0 °C / Reflux

2.1: potassium hydroxide / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

2.2: 24 h / 60 °C / Inert atmosphere

3.1: phosphorus(V) oxybromide / dichloromethane / Inert atmosphere; Reflux

With potassium hydroxide; phosphorus(V) oxybromide; In tetrahydrofuran; dichloromethane; ethylene glycol;
DOI:10.1039/c7ra01628j