1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline

Base Information

Chemical Name:1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline
CAS No.:20412-86-6
Molecular Formula:C₂₂H₂₉NO₄
Molecular Weight:371.477
Hs Code.:
DSSTox Substance ID:DTXSID40389225
Nikkaji Number:J1.654.632A

Synonyms:20412-86-6;1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline;Oprea1_002258;Oprea1_290033;DTXSID40389225;1-(3,4-Dimethoxybenzyl)-2-ethyl-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline;1-(3,4-Dimethoxybenzyl)-2-ethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:371.20965841
Heavy Atom Count:27
Complexity:448

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC

Technology Process of 1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline

There total 4 articles about 1-[(3,4-dimethoxyphenyl)methyl]-2-ethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(3,4-dimethoxy-benzyl)-2-ethyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolinium; chloride

: 20412-86-6
1-(3,4-dimethoxy-benzyl)-2-ethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

: (2-{2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-4,5-dimethoxy-phenyl}-ethyl)-ethyl-methyl-amine

Guidance literature:: With potassium thioacetate; In sulfolane; at 120 ℃; for 6h;
DOI:10.1039/b104843k

Reference yield:

: 1699-51-0,20412-65-1
laudanosine

: 20412-86-6
1-(3,4-dimethoxy-benzyl)-2-ethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: K₃PO₄*3H₂O / tetrahydrothiophene 1,1-dioxide / 2 h / 110 °C

2: 215 mg / Na₂S*9H₂O / tetrahydrothiophene 1,1-dioxide / 5 h / 120 °C / Hoffmann elimination

With sodium sulfide; potassium phosphate; In sulfolane;
DOI:10.1039/b104843k