Phytonadione

Base Information

Chemical Name:Phytonadione
CAS No.:79083-00-4
Deprecated CAS:10485-69-5,15973-57-6,50926-17-5,15973-57-6
Molecular Formula:C₃₁H₄₆O₂
Molecular Weight:450.705
Hs Code.:
European Community (EC) Number:201-564-2,234-330-3
NSC Number:760373
UNII:S5Z3U87QHF,MLF3D1712D
DSSTox Substance ID:DTXSID8023472
Nikkaji Number:J3.883K
Wikipedia:Phytomenadione
Wikidata:Q186093
NCI Thesaurus Code:C29365
RXCUI:8308
Metabolomics Workbench ID:29110
ChEMBL ID:CHEMBL1550

Synonyms:Aquamephyton;Konakion;Phyllohydroquinone;Phylloquinone;Phytomenadione;Phytonadione;Vitamin K 1;Vitamin K1

Suppliers and Price of Phytonadione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
VitaminK1-18O(Mixtureof1-18Oand4-18O)
10mg
$ 2200.00

Chemtos
Trans-VitaminK1(EPhytonadione)
25 mg
$ 1150.00

Total 7 raw suppliers

Chemical Property of Phytonadione

Chemical Property:

XLogP3:10.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:14
Exact Mass:450.349780706
Heavy Atom Count:33
Complexity:696

Purity/Quality:

99% ^*data from raw suppliers

VitaminK1-18O(Mixtureof1-18Oand4-18O) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Chemical Classes:Biological Agents -> Vitamins and Derivatives
Canonical SMILES:CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C
Isomeric SMILES:CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C
Recent ClinicalTrials:Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
Recent EU Clinical Trials:The effect of administering VITamin K preprocedural on the vitamin K dependent coagulation factors and the INR in patients anticoagulated with ACEnocoumarol
Uses Labelled Vitamin K1. Occurs widely in green plants, algae, photosynthetic bacteria. A representative lot was approximately 90% isotopically pure.

Technology Process of Phytonadione

There total 31 articles about Phytonadione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 16869-68-4
trans-1,4-Dihydro-vitamin K₁⁽²⁰⁾

: 84-80-0,16033-41-3,27696-10-2,79082-95-4,79082-96-5,79082-97-6,79083-00-4,81818-54-4,105017-37-6,132487-93-5,132487-94-6,132487-95-7
vitamin K₁

Guidance literature:: With dihydrogen peroxide; (Bu₃SnO)2CrO₂ on charcoal; In ethanol; at 40 ℃; for 1.5h;
DOI:10.1246/cl.1986.2075

Reference yield: 56.0%

: 84-80-0,16033-41-3,27696-10-2,79082-95-4,79082-96-5,79082-97-6,79083-00-4,81818-54-4,105017-37-6,132487-93-5,132487-94-6,132487-95-7
vitamin K₁

Guidance literature:: With magnesium sulfate; silver(l) oxide; In diethyl ether;

Reference yield:

: 64648-85-7
2-Bromo-3-Methyl-1,1,4,4-tetramethoxy-1,4-dihydronaphthalene

: 943232-38-0
(7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl bromide

: 58-27-5,34524-96-4
menadione

: 84-80-0,16033-41-3,27696-10-2,79082-95-4,79082-96-5,79082-97-6,79083-00-4,81818-54-4,105017-37-6,132487-93-5,132487-94-6,132487-95-7
vitamin K₁

Guidance literature:: With hydrogenchloride; n-butyllithium; copper (I) iodide; dimethylsulfide; water; Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1021/jo01291a002