(6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

Base Information

Chemical Name:(6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester
CAS No.:145301-11-7
Molecular Formula:C₃₀H₃₁N₃O₆
Molecular Weight:529.593
Hs Code.:

(6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

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Chemical Property of (6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

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Technology Process of (6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

There total 8 articles about (6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 145301-05-9
(E)-(5R,9R,13S,14R)-(+)-4,5α-Epoxy-3-methoxy-17-methyl-7-(4-nitrobenzyliden)-morphinan-6-on

: 14205-39-1
methyl 3-aminocrotonate

: 145301-11-7,145374-20-5
(6R,6aR,8S,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

: 145301-11-7,145374-20-5
(6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

Guidance literature:: With acetic acid; at 90 - 100 ℃; for 3h;
DOI:10.1002/ardp.19923251003

Reference yield: 11.0%

: 145301-05-9
(E)-(5R,9R,13S,14R)-(+)-4,5α-Epoxy-3-methoxy-17-methyl-7-(4-nitrobenzyliden)-morphinan-6-on

: 14205-39-1
methyl 3-aminocrotonate

: 145301-11-7,145374-20-5
(6R,6aR,8S,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

: 145301-11-7,145374-20-5
(6R,6aR,8R,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

Guidance literature:: With acetic acid; at 90 - 100 ℃; for 3h;
DOI:10.1002/ardp.19923251003

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 145301-11-7,145374-20-5
(6R,6aR,8S,12R,12aS)-(-)-1,12-Epoxy-5,6,6a,7,8,11-hexahydro-6,12a-iminoethano-2-methoxy-10,15-dimethyl-8-(4-nitrophenyl)-(12H)-naphtho<2,1-g>chinolin-9-carbonsaeuremethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / conc. NH₃ / ethanol / 3 h / Ambient temperature

2: 90 percent / conc. HCl, HOAc / 0.5 h / Heating

3: 17 percent / HOAc / 3 h / 90 - 100 °C

With hydrogenchloride; ammonium hydroxide; acetic acid; In ethanol;
DOI:10.1002/ardp.19923251003