4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole

Base Information

• Chemical Name: 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole
• CAS No.: 37697-64-6
• Molecular Formula: C5F8O2
• Molecular Weight: 244.041
• Hs Code.: 2932990090
• Mol file: 37697-64-6.mol

Synonyms:2,2-Bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole;Perfluoro-2,2-dimethyl-1,3-dioxole;

Chemical Property of 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole

Chemical Property:

• Vapor Pressure: 396mmHg at 25°C
• Refractive Index: 1.307
• Boiling Point: 43 °C at 760 mmHg
• PSA: 18.46000
• Density: 1.72 g/cm³
• LogP: 2.91970

Purity/Quality:

97% ^*data from raw suppliers

4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole

There total 4 articles about 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2,2-bis(trifluoromethyl)-4,5-dichloro-4,5-difluoro-1,3-dioxolane (60644-92-0) → 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole (37697-64-6)

Guidance literature:

With iodine; zinc; at 50 ℃; for 6h;

Reference yield:

4,5-dichloro-2,2-bis(trifluoromethyl)-1,3-dioxol → 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole (37697-64-6)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In N,N-dimethyl-formamide; at 150 ℃; for 7.66667h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield:

2,2-bis(trifluoromethyl)-4,4,5,5-tetrachloro-1,3-dioxacyclopentane (64499-81-6) → 4,5-Difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole (37697-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; iodine / dimethyl sulfoxide / 8.17 h / 80 - 120 °C / Inert atmosphere

2: 18-crown-6 ether; potassium fluoride / N,N-dimethyl-formamide / 7.67 h / 150 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; iodine; zinc; In dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

2,2-bis(trifluoromethyl)-4,5-dichloro-4,5-difluoro-1,3-dioxolane

2,2-bis(trifluoromethyl)-4,4,5,5-tetrachloro-1,3-dioxacyclopentane