23-oxa-25-hydroxyvitamin D₃

Base Information

Chemical Name:23-oxa-25-hydroxyvitamin D₃
CAS No.:84927-61-7
Molecular Formula:C₂₆H₄₂O₃
Molecular Weight:402.618
Hs Code.:

Synonyms:

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Chemical Property of 23-oxa-25-hydroxyvitamin D₃

Chemical Property:

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Technology Process of 23-oxa-25-hydroxyvitamin D₃

There total 15 articles about 23-oxa-25-hydroxyvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-97-0
vitamin D₃

: 84927-61-7
23-oxa-25-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / potassium permanganate / H₂O; ethanol / 1.) -10 deg C, 1 h, 2.) to 40 deg C, 10 min

2: 86 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

3: 1.) lead tetraacetate, 2.) Red-Al / 1.) benzene, pyridine, 25 deg C, 10 min, 2.) water, 1,5h

4: 91 percent / N-chlorosuccinimide, dimethyl sulfide / 1.) CH₂Cl₂, -20 deg C, 30 min, 2.) 0 deg C, 30 min

5: 1.) n-butyllithium, 2.) 5percent H₂O₂ / 1.) hexane, THF,-50 deg C, 15 min, 2.) chloroform, 1 min

6: 73 percent / n-butyllithium / tetrahydrofuran / 1.25 h / -78 deg C to room temp.

7: 61 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature

8: 1.) mercuric acetate, 2.) 3M NaOH, sodium borohydride / 1.) THF, water, 0 deg C, 2.25 h

With 1H-imidazole; lead(IV) acetate; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; N-chloro-succinimide; n-butyllithium; dimethylsulfide; mercury(II) diacetate; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00157a004

Reference yield:

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 84927-61-7
23-oxa-25-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / 1.) THF, hexane, 0 deg C, 2.) DMF, 75 to 78 deg C, 1.5h

2: 1.) mercuric acetate, 2.) 3M NaOH, sodium borohydride / 1.) water, THF, room temp., 1h

3: 79 percent / pyridinium trifluoroacetate, pyridinium dichromate / CH₂Cl₂ / 4 h / Ambient temperature

4: 98 percent / tetrahydrofuran / 2 h / Ambient temperature

5: 1.) n-butyllithium, 2.) tetra-n-butylammonium fluoride / 1.) THF, -78 deg C to room temp., 2.) THF, room temp., 2 h

With sodium hydroxide; sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; mercury(II) diacetate; tetrabutyl ammonium fluoride; pyridinium trifluroacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00157a004

Reference yield:

: 1236132-10-7
(S)-(Z)-[2-(5-hydroxy-2-methylene-cyclohexylidene)ethyl]di-phenylphosphineoxide

: 84927-61-7
23-oxa-25-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / imidazole / dimethylformamide

2: 73 percent / n-butyllithium / tetrahydrofuran / 1.25 h / -78 deg C to room temp.

3: 61 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature

4: 1.) mercuric acetate, 2.) 3M NaOH, sodium borohydride / 1.) THF, water, 0 deg C, 2.25 h

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; mercury(II) diacetate; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00157a004