Technology Process of N-(tert-Butoxycarbonyl)-trans-2,3-diphenyl-1,4-thiazane
There total 9 articles about N-(tert-Butoxycarbonyl)-trans-2,3-diphenyl-1,4-thiazane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: SOCl2 / CH2Cl2 / 16 h
2: 20percent NH4OH / acetonitrile / 16 h / Ambient temperature
3: 1) SOCl2, 2) 20percent NH4OH / 1) CH2Cl2, 0 deg C, 5 min, 2) MeCN, r.t., 16 h
4: 1) NaBH4, glac. AcOH, 2) 10percent aq. HCl / 1) dioxane, reflux, 22 h, 2) MeOH, r.t., 10 h
5: CH2Cl2 / 12 h / Ambient temperature
With
hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; acetic acid;
In
dichloromethane; acetonitrile;
DOI:10.1021/jo00041a029
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaOMe / methanol / 1) reflux, 2 h, 2) overnight, r.t.
2: SOCl2 / CH2Cl2 / 16 h
3: 20percent NH4OH / acetonitrile / 16 h / Ambient temperature
4: 1) SOCl2, 2) 20percent NH4OH / 1) CH2Cl2, 0 deg C, 5 min, 2) MeCN, r.t., 16 h
5: 1) NaBH4, glac. AcOH, 2) 10percent aq. HCl / 1) dioxane, reflux, 22 h, 2) MeOH, r.t., 10 h
6: CH2Cl2 / 12 h / Ambient temperature
With
hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium methylate; acetic acid;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00041a029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 20percent NH4OH / acetonitrile / 16 h / Ambient temperature
2: 1) SOCl2, 2) 20percent NH4OH / 1) CH2Cl2, 0 deg C, 5 min, 2) MeCN, r.t., 16 h
3: 1) NaBH4, glac. AcOH, 2) 10percent aq. HCl / 1) dioxane, reflux, 22 h, 2) MeOH, r.t., 10 h
4: CH2Cl2 / 12 h / Ambient temperature
With
hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; acetic acid;
In
dichloromethane; acetonitrile;
DOI:10.1021/jo00041a029
