Technology Process of (2E,8E)-5,9,13-Trimethyl-tetradeca-2,8,12-trienoic acid (S)-2-ethoxy-2-phenyl-ethyl ester
There total 6 articles about (2E,8E)-5,9,13-Trimethyl-tetradeca-2,8,12-trienoic acid (S)-2-ethoxy-2-phenyl-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / tris(triphenylphosphine)rhodium chloride / 3 h / 50 °C
2: 2.86 g / 3 percent aqueous sodium hydrogen carbonate / acetone; methanol / 2.5 h / Ambient temperature
3: 67 percent / CH2Cl2 / 20 h
4: 0.5 g / sodium hydroxide / methanol; H2O / 3 h / Heating
5: oxalyl chloride / benzene / 1.5 h / Ambient temperature
6: 1.) lithium aluminium hydride 2.) silver cyanide / 2.) benzene, reflux, 22 h
With
sodium hydroxide; Wilkinson's catalyst; lithium aluminium tetrahydride; silver cyanide; oxalyl dichloride; sodium hydrogencarbonate;
In
methanol; dichloromethane; water; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 0.5 g / sodium hydroxide / methanol; H2O / 3 h / Heating
2: oxalyl chloride / benzene / 1.5 h / Ambient temperature
3: 1.) lithium aluminium hydride 2.) silver cyanide / 2.) benzene, reflux, 22 h
With
sodium hydroxide; lithium aluminium tetrahydride; silver cyanide; oxalyl dichloride;
In
methanol; water; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.86 g / 3 percent aqueous sodium hydrogen carbonate / acetone; methanol / 2.5 h / Ambient temperature
2: 67 percent / CH2Cl2 / 20 h
3: 0.5 g / sodium hydroxide / methanol; H2O / 3 h / Heating
4: oxalyl chloride / benzene / 1.5 h / Ambient temperature
5: 1.) lithium aluminium hydride 2.) silver cyanide / 2.) benzene, reflux, 22 h
With
sodium hydroxide; lithium aluminium tetrahydride; silver cyanide; oxalyl dichloride; sodium hydrogencarbonate;
In
methanol; dichloromethane; water; acetone; benzene;
