8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Base Information

• Chemical Name: 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
• CAS No.: 1026159-92-1
• Molecular Formula: C₂₂H₁₄ClF₆N₃O₄
• Molecular Weight: 533.814

Synonyms:

Chemical Property of 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

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Technology Process of 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

There total 2 articles about 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(diphenylmethyl)-3-azetidine (147293-68-3) → 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (1026159-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) HCL, 2) H₂, Pd(OH)2/C / 1) Et₂O, 0 deg C; 2) EtOH, 60psi, r.t.

2: triethylamine, pyridine / 3 h / Heating

With pyridine; hydrogenchloride; palladium dihydroxide; hydrogen; triethylamine;

DOI:10.1021/jm00059a002

Reference yield:

8-Chloro-1-(2,4-difluoro-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (112282-65-2) + 3-azetidine hydrochloride → 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (1026159-92-1)

Guidance literature:

With pyridine; triethylamine; for 3h; Heating;

DOI:10.1021/jm00059a002

Reference yield:

8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-{3-[methyl-(2,2,2-trifluoro-acetyl)-amino]-azetidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (1026159-92-1) → 8-Chloro-1-(2,4-difluoro-phenyl)-6-fluoro-7-(3-methylamino-azetidin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

With sodium hydroxide; for 2h; Yield given; Heating;

DOI:10.1021/jm00059a002

upstream raw materials:

8-Chloro-1-(2,4-difluoro-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-(diphenylmethyl)-3-azetidine

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