7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

Base Information

Chemical Name:7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>
CAS No.:143843-08-7
Molecular Formula:C₅₇H₇₂ClNO₁₅Si
Molecular Weight:1074.73
Hs Code.:

7-(triethylsilyl)baccatin III 13-<N-benzoyl-O-((R<sup>*</sup>)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

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Technology Process of 7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

There total 4 articles about 7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 143843-03-2,143900-94-1,149494-55-3
(3R,4S)-1-benzoyl-3-<((R^*)-1'-ethoxyethyl)oxy>-4-(p-chlorophenyl)-2-azetidinone

: 115437-21-3
7-(triethylsilyl)baccatin III

: 143843-08-7,143900-97-4,149494-57-5
7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

Guidance literature:: With pyridine; dmap; at 25 ℃; for 24h;
DOI:10.1021/jm00100a031

Reference yield:

: 143843-00-9
(3R,4S)-3-hydroxy-4-(p-chlorophenyl)-2-azetidinone

: 143843-08-7,143900-97-4,149494-57-5
7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / p-TSA / tetrahydrofuran / 0.5 h

2: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.75 h

3: 89 percent / 4-(dimethylamino)pyridine, pyridine / 24 h / 25 °C

With pyridine; dmap; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00100a031

Reference yield:

: 143843-01-0,143900-92-9,149494-58-6
(3R,4S)-3-<((R^*)-1'-ethoxyethyl)oxy>-4-(p-chlorophenyl)-2-azetidinone

: 143843-08-7,143900-97-4,149494-57-5
7-(triethylsilyl)baccatin III 13-*)-1''-ethoxyethyl)-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate>

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.75 h

2: 89 percent / 4-(dimethylamino)pyridine, pyridine / 24 h / 25 °C

With pyridine; dmap; triethylamine; In dichloromethane;
DOI:10.1021/jm00100a031