C₃₅H₃₆F₂O₆S₂

Base Information

• Chemical Name: C₃₅H₃₆F₂O₆S₂
• CAS No.: 1365915-07-6
• Molecular Formula: C₃₅H₃₆F₂O₆S₂
• Molecular Weight: 654.796
• Mol file: 1365915-07-6.mol

Synonyms:

Chemical Property of C₃₅H₃₆F₂O₆S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₆F₂O₆S₂

There total 4 articles about C₃₅H₃₆F₂O₆S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

4-{[3-(methylthio)phenyl]thio}benzaldehyde (1159113-26-4) + 6α,9α-difluoro-11β,16α,17α,21-tetra-hydroxypregna-1,4-diene-3,20-dione (807-38-5,67438-36-2) → (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8-(4-{[3-(methylthio)phenyl]thio}phenyl)-4a,4b,5,6,6a,6-b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho-[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (1159113-31-1) + C35H36F2O6S2 (1365915-07-6)

Guidance literature:

With trifluorormethanesulfonic acid; magnesium sulfate; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/op200257g

Reference yield:

fluocinolone Acetonide (67-73-2) → (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8-(4-{[3-(methylthio)phenyl]thio}phenyl)-4a,4b,5,6,6a,6-b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho-[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (1159113-31-1) + C35H36F2O6S2 (1365915-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrafluoroboric acid / water / 2 h / 22 °C

2: trifluorormethanesulfonic acid; magnesium sulfate / 1,4-dioxane / 20 °C

With tetrafluoroboric acid; trifluorormethanesulfonic acid; magnesium sulfate; In 1,4-dioxane; water;

DOI:10.1021/op200257g

Reference yield:

3-mercaptothiophenol (626-04-0) → (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8-(4-{[3-(methylthio)phenyl]thio}phenyl)-4a,4b,5,6,6a,6-b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho-[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (1159113-31-1) + C35H36F2O6S2 (1365915-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 2-methyltetrahydrofuran; water / 0.42 h / 2 °C

2: potassium carbonate / acetonitrile / 20 °C

3: trifluorormethanesulfonic acid; magnesium sulfate / 1,4-dioxane / 20 °C

With trifluorormethanesulfonic acid; magnesium sulfate; potassium carbonate; sodium hydroxide; In 2-methyltetrahydrofuran; 1,4-dioxane; water; acetonitrile;

DOI:10.1021/op200257g

upstream raw materials:

4-{[3-(methylthio)phenyl]thio}benzaldehyde

6α,9α-difluoro-11β,16α,17α,21-tetra-hydroxypregna-1,4-diene-3,20-dione

fluocinolone Acetonide

3-mercaptothiophenol