1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione

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Chemical Name:1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione
CAS No.:77445-74-0
Molecular Formula:C₃₆H₂₄Cl₂F₂N₄O₄
Molecular Weight:685.514
Hs Code.:

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Chemical Property of 1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione

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Technology Process of 1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione

There total 3 articles about 1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 110-85-0
piperazine

: 77445-93-3
2-(2-chloro-4-fluorophenyl)-3-indolylglyoxalyl chloride

: 77445-74-0
1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione

Guidance literature:: In diethyl ether;
DOI:10.1007/BF00903661

Reference yield:

: N-[1-(2-Chloro-4-fluoro-phenyl)-eth-(E)-ylidene]-N'-phenyl-hydrazine

: 77445-74-0
1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / polyphosphoric acid

2: diethyl ether / 0.25 h

3: 88 percent / diethyl ether

With PPA; In diethyl ether;
DOI:10.1007/BF00903661

Reference yield:

: 77445-10-4
2-(2-Chloro-4-fluoro-phenyl)-1H-indole

: 77445-74-0
1-[2-(2-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-(4-{2-[2-(2-chloro-4-fluoro-phenyl)-1H-indol-3-yl]-2-oxo-acetyl}-piperazin-1-yl)-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0.25 h

2: 88 percent / diethyl ether

In diethyl ether;
DOI:10.1007/BF00903661