2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane

Base Information

• Chemical Name: 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane
• CAS No.: 122886-43-5
• Molecular Formula: C₃₃H₂₇N₃O₄
• Molecular Weight: 529.595

Synonyms:

Chemical Property of 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane

Chemical Property:

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Technology Process of 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane

There total 3 articles about 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

N-phenyl-maleimide (941-69-5) + N-pyridoxylidene-5-amino-5H-dibenzocycloheptene (122886-32-2) → 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane (122886-43-5)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h;

DOI:10.1016/S0040-4020(01)86100-7

Reference yield:

5-amino-5H-dibenzocycloheptene (31721-90-1) → 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane (122886-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / potassium hydroxide / 0.5 h / Ambient temperature

2: 44 percent / acetonitrile / 24 h / 80 °C

With potassium hydroxide; In acetonitrile;

DOI:10.1016/S0040-4020(01)86100-7

Reference yield:

pyridoxal hydrochloride (65-22-5) → 2,2-spiro(5',5'-dibenzocycloheptyl)-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane (122886-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / potassium hydroxide / 0.5 h / Ambient temperature

2: 44 percent / acetonitrile / 24 h / 80 °C

With potassium hydroxide; In acetonitrile;

DOI:10.1016/S0040-4020(01)86100-7

upstream raw materials:

N-phenyl-maleimide

N-pyridoxylidene-5-amino-5H-dibenzocycloheptene

5-amino-5H-dibenzocycloheptene

pyridoxal hydrochloride

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