Technology Process of Z-Thr(Boc-Pro-MeTyr(Me))-Ist-Hip-Leu-OTCE
There total 61 articles about Z-Thr(Boc-Pro-MeTyr(Me))-Ist-Hip-Leu-OTCE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 15h;
0 deg C -> room temperature;
DOI:10.1055/s-1991-26448
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 75 percent / NEt3 / ethyl acetate / 48 h / 20 °C
2: 98 percent / dicyclohexylcarbodiimide / 4-dimethylaminopyridine / CH2Cl2 / 15 h / -30 deg C -> 20 deg C
3: 88 percent / 5 N HCl / dioxane / 2 h / 20 °C
4: 93 percent / 1 N NaHCO3 / CHCl3
5: 95 percent / N,N-bis<2-oxo-3-oxazolidinyl>phosphorodiamidic chloride, N-ethyldiisopropylamine / CH2Cl2 / 15 h / 0 deg C -> 20 deg C
6: 95 percent / Zn-powder, 90 percent aq. AcOH / 20 °C
7: 70 percent / N,N-bis<2-oxo-3-oxazolidinyl>phosphorodiamidic chloride, N-ethyldiisopropylamine / CH2Cl2 / 15 h / 0 deg C -> room temperature
With
hydrogenchloride; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; sodium hydrogencarbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; zinc;
dmap;
In
1,4-dioxane; dichloromethane; chloroform; ethyl acetate;
DOI:10.1055/s-1991-26448
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 88 percent / triethylamine, dicyclohexylcarbodiimide / CH2Cl2 / 20 h / 0 deg C -> 20 deg C
2: 78 percent / N,N-pentamethylenethiourea, triethylamine / dioxane / 3 h / 70 °C
3: 95 percent / dicyclohexylcarbodiimide / 4-dimethylaminopyridine / CH2Cl2 / 20 h / -20 deg C -> 20 deg C
4: 50 percent aq. HF / acetonitrile / 15 h / 20 °C
5: 6 N HCl / dioxane / 1 h / 20 °C
6: 70 percent / N,N-bis<2-oxo-3-oxazolidinyl>phosphorodiamidic chloride, N-ethyldiisopropylamine / CH2Cl2 / 15 h / 0 deg C -> room temperature
With
hydrogenchloride; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; hydrogen fluoride; piperidine-1-carbothioamide; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
dmap;
In
1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1055/s-1991-26448
