(Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester
CAS No.:132487-18-4
Molecular Formula:C₂₆H₄₅N₂O₁₀PSi
Molecular Weight:604.71
Hs Code.:

(Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

Chemical Property:

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Technology Process of (Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

There total 1 articles about (Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101766-04-5
N-butyryl-4(R)-(methoxycarbonyl)-1,3-thiazolidine-2-thione

: 122230-35-7
p-nitrobenzyl aminodimethylphosphonoacetate

: 132400-14-7,132487-18-4
(Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

Guidance literature:: With pyridine; N,N-dimethylaminpyridine; benzotriazol-1-ol; Yield given. Multistep reaction; 1) CH₃CN, 1 h, room temperature, 2) CH₃CN, 84 h, room temperature;
DOI:10.1016/S0040-4020(01)81463-0

Reference yield: 66.0%

: 132400-14-7,132487-18-4
(Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

: 122230-27-7,132488-69-8,132488-70-1
p-Nitrobenzyl α-(dimethylphosphono)-α-[3α-ethyl-4β-[2-[dimethyl-(2,3-dimethylbutan-2-yl)silyloxy]ethyl]-azetidin-2-one-1-yl]acetate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81463-0

Reference yield:

: 132400-14-7,132487-18-4
(Dimethoxy-phosphoryl)-{(2R,3S)-5-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-ethyl-3-hydroxy-pentanoylamino}-acetic acid 4-nitro-benzyl ester

: 132400-15-8,132487-19-5
(Dimethoxy-phosphoryl)-[(2R,3R)-3-ethyl-2-(2-hydroxy-ethyl)-4-oxo-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / PPh₃, di-t-butylazodicarboxylate / tetrahydrofuran / 24 h / Ambient temperature

2: 62 percent / n-tetrabutylammonium fluoride / tetrahydrofuran / 16 h / Ambient temperature

With di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)81463-0