BM-1074

Base Information

Chemical Name:BM-1074
CAS No.:1391108-10-3
Molecular Formula:C₅₀H₅₇ClN₈O₇S₃
Molecular Weight:1013.7
Hs Code.:
Mol file:1391108-10-3.mol

Synonyms:

Suppliers and Price of BM-1074

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BM-1074
10mg
$ 1680.00

Total 19 raw suppliers

Chemical Property of BM-1074

Chemical Property:

PKA:2.32±0.40(Predicted)
Density:1.34±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

BM-1074 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses BM-1074 is a potent Bcl-2/Bcl-xL inhibitor which is capable of achieving rapid, complete, and durable tumor regression in vivo.

Technology Process of BM-1074

There total 10 articles about BM-1074 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₇IO₃

: 1391108-10-3
C₅₀H₅₇ClN₈O₇S₃

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide / 5 h / 70 °C

2: methanol / 24 h / Sealed tube

3: sulfuric acid / dichloromethane; tetrahydrofuran / 0.17 h / 0 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Reflux

5: dmap / 1,2-dichloro-ethane / Reflux

6: L-proline; copper(l) iodide / dimethyl sulfoxide / Inert atmosphere; Heating

7: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 760.05 Torr / Inert atmosphere

8: pyridine / 0.5 h / 0 °C

9: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With pyridine; dmap; copper(l) iodide; oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; L-proline; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis / 6: |Ullmann Condensation;
DOI:10.1021/jm4001105

Reference yield:

: 1428146-19-3
5-(4-chlorophenyl)-1-isopropyl-2-methyl-N-(methylsulfonyl)-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxamide

: 1391108-10-3
C₅₀H₅₇ClN₈O₇S₃

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 760.05 Torr / Inert atmosphere

2: pyridine / 0.5 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With pyridine; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm4001105

Reference yield:

: 1428145-83-8
tert-butyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1391108-10-3
C₅₀H₅₇ClN₈O₇S₃

Guidance literature:: Multi-step reaction with 8 steps

1: methanol / 24 h / Sealed tube

2: sulfuric acid / dichloromethane; tetrahydrofuran / 0.17 h / 0 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Reflux

4: dmap / 1,2-dichloro-ethane / Reflux

5: L-proline; copper(l) iodide / dimethyl sulfoxide / Inert atmosphere; Heating

6: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 760.05 Torr / Inert atmosphere

7: pyridine / 0.5 h / 0 °C

8: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With pyridine; dmap; copper(l) iodide; oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; L-proline; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: |Paal-Knorr Pyrrole Synthesis / 5: |Ullmann Condensation;
DOI:10.1021/jm4001105