Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

Base Information

Chemical Name:Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester
CAS No.:195703-40-3
Molecular Formula:C₃₂H₄₃NO₁₂
Molecular Weight:633.693
Hs Code.:

Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

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Chemical Property of Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

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Technology Process of Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

There total 6 articles about Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 205493-65-8
Benzoic acid (R)-((2R,4R,5R,6R)-4-hydroxymethyl-2-methoxy-5,6-dimethyl-tetrahydro-pyran-2-yl)-methoxycarbonyl-methyl ester

: 195703-40-3
Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: n-Bu₃P / tetrahydrofuran / 0 °C

2: 1.) H₂O₂, 2.) Et₃N / 1.) THF, room temperature, 2.) benzene, reflux

3: n-PrSLi / hexamethylphosphoric acid triamide

4: DMAP / CH₂Cl₂ / 0 - 20 °C

5: CH₂Cl₂ / Ambient temperature

With dmap; tributylphosphine; dihydrogen peroxide; lithium n-propylmercaptide; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0960-894X(97)00365-X

Reference yield:

: 205493-66-9
Benzoic acid (R)-methoxycarbonyl-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-methyl ester

: 195703-40-3
Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: n-PrSLi / hexamethylphosphoric acid triamide

2: DMAP / CH₂Cl₂ / 0 - 20 °C

3: CH₂Cl₂ / Ambient temperature

With dmap; lithium n-propylmercaptide; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0960-894X(97)00365-X

Reference yield:

: Benzoic acid (R)-((2R,4R,5R,6R)-4-formyl-2-methoxy-5,6-dimethyl-tetrahydro-pyran-2-yl)-methoxycarbonyl-methyl ester

: 195703-40-3
Benzoic acid (R)-((2R,5R,6R)-2-methoxy-5,6-dimethyl-4-methylene-tetrahydro-pyran-2-yl)-[(4R,4aS,6R,8S,8aR)-8-methoxy-7,7-dimethyl-6-((S)-2-oxo-[1,3]dioxolan-4-ylmethyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-4-ylcarbamoyl]-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Zn(BH₄)2 / diethyl ether / -78 °C

2: n-Bu₃P / tetrahydrofuran / 0 °C

3: 1.) H₂O₂, 2.) Et₃N / 1.) THF, room temperature, 2.) benzene, reflux

4: n-PrSLi / hexamethylphosphoric acid triamide

5: DMAP / CH₂Cl₂ / 0 - 20 °C

6: CH₂Cl₂ / Ambient temperature

With dmap; zinc(II) tetrahydroborate; tributylphosphine; dihydrogen peroxide; lithium n-propylmercaptide; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(97)00365-X