(2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane

Base Information

• Chemical Name: (2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane
• CAS No.: 404344-61-2
• Molecular Formula: C₃₇H₄₀N₂O₁₁S
• Molecular Weight: 720.797
• Mol file: 404344-61-2.mol

Synonyms:

Chemical Property of (2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane

There total 1 articles about (2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2,3,4,5-tetra-O-acetyl-D-arabinose (3891-58-5) + 3-(4-methoxyphenyl)-2-(N-methylbenzylamino)-5-phenyl-1,3-thiazolium-4-olate (173094-32-1) → (2R,3R)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane (404344-58-7) + (2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane (404344-61-2) + 3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1021/jo034188r

Reference yield: 37.0%

(2R,3R)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane (404344-58-7) + (2S,3S)-3-(1',2',3',4'-tetra-O-acetyl-D-arabino-tetritol-1'-yl)-2-[4-benzyl-2-(4-methoxyphenyl)-1,3-dioxo-2,4-diazapentyl]-2-phenylthiirane (404344-61-2) → (E)-N-(N'-benzyl-N'-methylcarbamoyl)-N-(4-methoxyphenyl)-2,3-dideoxy-2-phenyl-4,5,6,7-tetra-O-acetyl-D-arabino-hept-2-enamide

Guidance literature:

In dimethyl sulfoxide; at 100 ℃; for 1h;

DOI:10.1021/jo034188r

upstream raw materials:

2,3,4,5-tetra-O-acetyl-D-arabinose

3-(4-methoxyphenyl)-2-(N-methylbenzylamino)-5-phenyl-1,3-thiazolium-4-olate