4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride

Base Information

• Chemical Name: 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride
• CAS No.: 595570-77-7
• Molecular Formula: C₃₂H₄₅FN₄O₆SSi
• Molecular Weight: 660.882
• Mol file: 595570-77-7.mol

Synonyms:

Chemical Property of 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride

There total 6 articles about 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride (595570-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide

2: ammonium formate; 10 percent Pd/C / methanol / Heating

3: K₂CO₃ / dimethylformamide

With palladium on activated charcoal; ammonium formate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00639-X

Reference yield:

4-fluorosulfonylbenzoyl chloride (402-55-1) → 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride (595570-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaI / acetone

2: K₂CO₃ / dimethylformamide

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0960-894X(02)00639-X

Reference yield:

4-(5-chloro-pentanoyl)-benzenesulfonyl fluoride (525603-26-3) → 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride (595570-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetone

2: K₂CO₃ / dimethylformamide

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0960-894X(02)00639-X

upstream raw materials:

4-(5-iodo-pentanoyl)-benzenesulfonyl fluoride

8-(1R,2S,4S)-Bicyclo[2.2.1]hept-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

(2-trimethylethylsilylethoxy)methyl chloride

4-fluorosulfonylbenzoyl chloride