5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Base Information

Chemical Name:5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine
CAS No.:452304-73-3
Molecular Formula:C₅₄H₆₆N₄O₁₀SSi₂
Molecular Weight:1019.38
Hs Code.:

5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Synonyms:

Suppliers and Price of 5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

There total 5 articles about 5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₄H₆₆N₄O₈SSi₂

: 452304-73-3
5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Guidance literature:: With Oxone; sodium acetate; In tetrahydrofuran; methanol; water; at 20 ℃; for 1.5h;
DOI:10.1002/1522-2675(200209)85:9<2777::AID-HLCA2777>3.0.CO;2-1

Reference yield:

: 146557-80-4
1-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}thymine

: 452304-73-3
5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / PPh₃; DIAD / tetrahydrofuran / 2 h / 0 - 20 °C

2: 88 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 0 °C

3: Cs₂CO₃ / tetrahydrofuran; dimethylformamide / 20 °C

4: 148 mg / Oxone; AcONa / tetrahydrofuran; methanol; H₂O / 1.5 h / 20 °C

With Oxone; sodium hydroxide; di-isopropyl azodicarboxylate; sodium acetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1002/1522-2675(200209)85:9<2777::AID-HLCA2777>3.0.CO;2-1

Reference yield:

: 146557-69-9
1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine

: 452304-73-3
5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)thymidylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaBH₄ / ethanol / 2 h / 20 °C

2: 62 percent / PPh₃; DIAD / tetrahydrofuran / 2 h / 0 - 20 °C

3: 88 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 0 °C

4: Cs₂CO₃ / tetrahydrofuran; dimethylformamide / 20 °C

5: 148 mg / Oxone; AcONa / tetrahydrofuran; methanol; H₂O / 1.5 h / 20 °C

With Oxone; sodium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; sodium acetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1002/1522-2675(200209)85:9<2777::AID-HLCA2777>3.0.CO;2-1