Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine
• CAS No.: 133272-04-5
• Molecular Formula: C₆H₁₅N*C₂₄H₃₀N₅O₉P
• Molecular Weight: 664.696

Synonyms:

Chemical Property of Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

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Technology Process of Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine

There total 2 articles about Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

9-(2-O-acetyl-5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)-6-hydroxy-2-isobutyramidopurin (133294-70-9) → 9-(5-O-benzoyl-3-desoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)-6-hydroxy-2-isobutyramidopurin (133272-08-9) + Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (133272-04-5) + C26H31N5O10P(1-)*Na(1+) (133272-05-6)

Guidance literature:

With pyridine; hydroxylamine acetate; for 66h; Yields of byproduct given; Ambient temperature;

Reference yield: 40.0%

1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-3-O-(diethoxyphosphonomethyl)-β-D-ribofuranose (31843-77-3) + N2-isobutyryl-guanine (21047-89-2) → 9-ethyl-6-hydroxy-2-isobutyramidopurin (133272-03-4) + 9-(2-O-acetyl-5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)-6-hydroxy-2-isobutyramidopurin (133294-70-9) + Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine (133272-04-5) + C26H31N5O10P(1-)*Na(1+) (133272-05-6)

Guidance literature:

With chloro-trimethyl-silane; potassium nonaflate; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; for 6h; Heating;

upstream raw materials:

1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-3-O-(diethoxyphosphonomethyl)-β-D-ribofuranose

N²-isobutyryl-guanine

9-(2-O-acetyl-5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)-6-hydroxy-2-isobutyramidopurin

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