N-(2-Chloro-4-methyl-3-pyridyl)acetamide

Base Information

Chemical Name:N-(2-Chloro-4-methyl-3-pyridyl)acetamide
CAS No.:76006-00-3
Molecular Formula:C₈H₉ClN₂O
Molecular Weight:184.625
Hs Code.:2933399990
DSSTox Substance ID:DTXSID901267004
Mol file:76006-00-3.mol

Synonyms:N-(2-Chloro-4-methyl-3-pyridyl)acetamide;76006-00-3;N-(2-chloro-4-methylpyridin-3-yl)acetamide;Acetamide, N-(2-chloro-4-methyl-3-pyridinyl)-;N-(2-Chloro-4-methyl-3-pyridinyl)acetamide;DTXSID901267004;BDA00600;AC6770;MFCD21244018;AKOS014828349;SB54044;CS-12090;SY037248;CS-0455564;FT-0721029;N-(2-Chloro-4-methyl-pyridin-3-yl)-acetamide;A915104

Suppliers and Price of N-(2-Chloro-4-methyl-3-pyridyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
N-(2-chloro-4-methyl-3-pyridyl)acetamide
1 g
$ 269.00

SynQuest Laboratories
N-(2-chloro-4-methyl-3-pyridyl)acetamide
5 g
$ 784.00

Chemcia Scientific
N-(2-Chloro-4-methyl-pyridin-3-yl)-acetamide 95%
5 G
$ 435.00

Alichem
N-(2-Chloro-4-methyl-3-pyridyl)acetamide
5g
$ 400.00

AK Scientific
N-(2-Chloro-4-methyl-3-pyridyl)acetamide
1g
$ 222.00

Total 7 raw suppliers

Chemical Property of N-(2-Chloro-4-methyl-3-pyridyl)acetamide

Chemical Property:

Melting Point:119-120 °C
Boiling Point:340.1±42.0 °C(Predicted)
PKA:13.27±0.70(Predicted)
Density:1.282±0.06 g/cm3(Predicted)
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:184.0403406
Heavy Atom Count:12
Complexity:174

Purity/Quality:

97% ^*data from raw suppliers

N-(2-chloro-4-methyl-3-pyridyl)acetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=NC=C1)Cl)NC(=O)C

Technology Process of N-(2-Chloro-4-methyl-3-pyridyl)acetamide

There total 5 articles about N-(2-Chloro-4-methyl-3-pyridyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6635-86-5,67476-70-4
2-amino-4-methyl-3-nitropyridine

: 76006-00-3
3-acetamido-2-chloro-4-methylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium nitrite; sulfuric acid / water

2: trichlorophosphate / 110 °C

3: tin(II) chloride dihdyrate; hydrogenchloride / 55 °C

4: dichloromethane / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; sodium nitrite; trichlorophosphate; In dichloromethane; water;
DOI:10.1248/cpb.c16-00704

Reference yield:

: 23056-39-5
2-chloro-3-nitro-4-methylpyridine

: 108-24-7
acetic anhydride

: 76006-00-3
3-acetamido-2-chloro-4-methylpyridine

Guidance literature:: 2-chloro-3-nitro-4-methylpyridine; With hydrogenchloride; tin(II) chloride dihdyrate; at 55 ℃;

acetic anhydride; In dichloromethane; at 20 ℃;
DOI:10.2174/1573406415666190222130225

Reference yield:

: 23056-39-5
2-chloro-3-nitro-4-methylpyridine

: 76006-00-3
3-acetamido-2-chloro-4-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride, conc. hydrochloric acid / diethyl ether / 3 h / 100 °C

2: 2.1 g / toluene / 2 h / 100 °C

With hydrogenchloride; tin(ll) chloride; In diethyl ether; toluene;