2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran

Base Information

• Chemical Name: 2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran
• CAS No.: 97747-43-8
• Molecular Formula: C₂₁H₃₀O₂Se
• Molecular Weight: 393.428
• Mol file: 97747-43-8.mol

Synonyms:

Chemical Property of 2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran

There total 1 articles about 2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanone (76339-71-4) → 2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran (97747-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 19 percent / diisobutylaluminum hydride (DIBAH) / toluene / 3 h / -78 °C

2: PPTS / CH₂Cl₂ / 16 h / Ambient temperature

With pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1021/jo00218a026

Reference yield:

2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran (97747-43-8) → C21H30O3Se (97747-44-9)

Guidance literature:

With pyridine; dihydrogen peroxide; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1021/jo00218a026

Reference yield:

2-((1R,2S,3R,5S)-5-Isopropenyl-2-methyl-3-phenylselanyl-cyclohexyloxy)-tetrahydro-pyran (97747-43-8) → (1R,2R,5S)-2-methyl-5-(1-methylethenyl)-1-((tetrahydropyran-2-yl)oxy)-3-cyclohexene (97690-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, 15percent H₂O₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

2: pyridine / CCl₄ / 0.5 h / Heating

With pyridine; dihydrogen peroxide; In tetrachloromethane; dichloromethane;

DOI:10.1021/jo00218a026

upstream raw materials:

(2S,3R,5S)-2-methyl-5-(1-methylethenyl)-3-(phenylseleno)-cyclohexanone

Downstream raw materials:

C₂₁H₃₀O₃Se

(4S,5R)-4-hydroxy-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enone

(1R,2R,5S)-2-methyl-5-(1-methylethenyl)-3-cyclohexen-1-ol

(1R,2R,5S)-2-methyl-5-(1-methylethenyl)-1-((tetrahydropyran-2-yl)oxy)-3-cyclohexene