1-CHLORO-4-THIEN-2-YLPHTHALAZINE

Base Information

• Chemical Name: 1-CHLORO-4-THIEN-2-YLPHTHALAZINE
• CAS No.: 124959-34-8
• Molecular Formula: C₁₂H₇ClN₂S
• Molecular Weight: 246.72
• Mol file: 124959-34-8.mol

Synonyms:1-chloro-4-thiophen-2-yl-phthalazine;

Chemical Property of 1-CHLORO-4-THIEN-2-YLPHTHALAZINE

Chemical Property:

• Melting Point: 134.5-135.5 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 446.3±35.0 °C(Predicted)
• PKA: 1.14±0.30(Predicted)
• PSA: 54.02000
• Density: 1.396±0.06 g/cm3(Predicted)
• LogP: 4.01170

Purity/Quality:

97% ^*data from raw suppliers

1-CHLORO-4-THIEN-2-YLPHTHALAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-CHLORO-4-THIEN-2-YLPHTHALAZINE

There total 7 articles about 1-CHLORO-4-THIEN-2-YLPHTHALAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(thiophen-2-yl)phthalazin-1(2H)-one (137382-45-7) → 1-chloro-4-(2'-thienyl)-phthalazine (124959-34-8)

Guidance literature:

With trichlorophosphate; at 110 - 120 ℃; for 4h;

DOI:10.1002/jhet.5570420701

Reference yield:

methyl-2-(thiophene-2-carbonyl)benzoate (873548-66-4) → 1-chloro-4-(2'-thienyl)-phthalazine (124959-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / NH₂NH₂*H₂O / ethanol / 16 h / Heating

2: 99 percent / POCl₃ / 4 h / 110 - 120 °C

With hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1002/jhet.5570420701

Reference yield:

monoethyl phthalate (2306-33-4) → 1-chloro-4-(2'-thienyl)-phthalazine (124959-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / CH₂Cl₂ / 4.5 h / Heating

2: 75 percent / SnCl₄ / CH₂Cl₂ / 20 °C

3: 84 percent / NH₂NH₂*H₂O / ethanol / 16 h / Heating

4: 99 percent / POCl₃ / 4 h / 110 - 120 °C

With thionyl chloride; tin(IV) chloride; hydrazine hydrate; trichlorophosphate; In ethanol; dichloromethane; 2: Friedel-Crafts reaction;

DOI:10.1002/jhet.5570420701

upstream raw materials:

4-(thiophen-2-yl)phthalazin-1(2H)-one

methyl-2-(thiophene-2-carbonyl)benzoate

monoethyl phthalate

ethyl-2-(thiophene-2-carbonyl)benzoate