(E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone

Base Information

• Chemical Name: (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone
• CAS No.: 126917-19-9
• Molecular Formula: C₂₃H₁₉F₅N₄O₂
• Molecular Weight: 478.421
• Mol file: 126917-19-9.mol

Synonyms:

Chemical Property of (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone

There total 4 articles about (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

trans-4-(trifluoromethyl)cinnamoyl chloride (105919-36-6,120681-07-4) + (4R*,5R*)-5-(2,4-Difluorophenyl)-4-methyl-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine (126916-45-8,132507-79-0,138457-44-0) → (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone (126917-19-9,132616-97-8)

Guidance literature:

With pyridine; for 1h; ice-cooling;

DOI:10.1248/cpb.38.2476

Reference yield:

threo-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol (132507-89-2,132507-94-9,133775-25-4,135270-05-2,135270-11-0,135272-36-5) → (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone (126917-19-9,132616-97-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / pyridine / 2 h / Ambient temperature

2: 84 percent / NaN₃, NH₄Cl / dimethylformamide / 15 h / 115 °C

3: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

4: benzene / 3 h / Heating

5: 59 percent / pyridine / 1 h / ice-cooling

With pyridine; sodium azide; hydrogen; ammonium chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.38.2476

Reference yield:

Methanesulfonic acid (1S,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester (126945-34-4,132507-78-9,133775-26-5,135270-06-3,135270-09-6,135270-12-1) → (E)-1-[(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone (126917-19-9,132616-97-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / NaN₃, NH₄Cl / dimethylformamide / 15 h / 115 °C

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h

3: benzene / 3 h / Heating

4: 59 percent / pyridine / 1 h / ice-cooling

With pyridine; sodium azide; hydrogen; ammonium chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.38.2476

upstream raw materials:

trans-4-(trifluoromethyl)cinnamoyl chloride

(4R*,5R*)-5-(2,4-Difluorophenyl)-4-methyl-5-<(1H-1,2,4-triazol-1-yl)methyl>oxazolidine

(2R*,3R*)-3-Amino-2-(2,4-difluoropropyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

threo-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol