3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N⁶-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N⁶-benzoyladenosine P 2-cyanoethyl ester

Base Information

• Chemical Name: 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N⁶-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N⁶-benzoyladenosine P 2-cyanoethyl ester
• CAS No.: 81691-43-2
• Molecular Formula: C₆₉H₆₂N₁₁O₁₆P
• Molecular Weight: 1332.29

Synonyms:

Chemical Property of 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N⁶-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N⁶-benzoyladenosine P 2-cyanoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N⁶-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N⁶-benzoyladenosine P 2-cyanoethyl ester

There total 5 articles about 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N⁶-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N⁶-benzoyladenosine P 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-benzoyl chloride (874-60-2) → 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N6-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N6-benzoyladenosine P 2-cyanoethyl ester (81691-43-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) dibutyltin oxide, 2.) triethylamine / 1.) methanol, reflux, 1 h, 2.) room temp., 30 min

2: 79 percent / pyridine / 16 h / Ambient temperature

3: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 16 h / 20 °C

4: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 24 h / Ambient temperature

With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; di(n-butyl)tin oxide; triethylamine; In pyridine;

Reference yield:

N6-benzoyl-3'-O-p-methylbenzoyladenosine (81691-40-9) → 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N6-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N6-benzoyladenosine P 2-cyanoethyl ester (81691-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / pyridine / 16 h / Ambient temperature

2: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 16 h / 20 °C

3: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 24 h / Ambient temperature

With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine;

Reference yield:

5'-monomethoxytrityl-3'-O-p-methylbenzoyl-N6-benzoyladenosine (81691-41-0) → 3'-O-p-methylbenzoyl-5'-O-monomethoxytrityl-N6-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N6-benzoyladenosine P 2-cyanoethyl ester (81691-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 16 h / 20 °C

2: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 24 h / Ambient temperature

With 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine;

upstream raw materials:

N⁶-benzoyl-9-(2',3'-di-O-acetyl-β-D-ribofuranosyl)adenine

4-Methyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-cyano-ethoxy)-hydroxy-phosphoryloxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

4-methyl-benzoyl chloride

N⁶-benzoyl-3'-O-p-methylbenzoyladenosine

Downstream raw materials:

3'-O-p-methylbenzoyl-N⁶-benzoyladenylyl-(2'->5')-2',3'-di-O-acetyl-N⁶-benzoyladenosine P 2-cyanoethyl ester

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