1L-N¹-benzyloxycarbonyl-O⁶-[2-benzyloxycarbonylamino-O⁶-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine

Base Information

• Chemical Name: 1L-N¹-benzyloxycarbonyl-O⁶-[2-benzyloxycarbonylamino-O⁶-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine
• CAS No.: 68537-56-4
• Molecular Formula: C₆₂H₆₁N₅O₂₅S₂
• Molecular Weight: 1340.32
• Mol file: 68537-56-4.mol

Synonyms:

Chemical Property of 1L-N¹-benzyloxycarbonyl-O⁶-[2-benzyloxycarbonylamino-O⁶-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1L-N¹-benzyloxycarbonyl-O⁶-[2-benzyloxycarbonylamino-O⁶-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine

There total 4 articles about 1L-N¹-benzyloxycarbonyl-O⁶-[2-benzyloxycarbonylamino-O⁶-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1L-N1-benzyloxycarbonyl-O6-(2-benzyloxycarbonylamino-O4,O6-cyclohexane-1,1-diyl-α-D-ribo-2,3-dideoxy-hexopyranosyl)-N3,O4-carbonyl-2-deoxy-streptamine (63604-34-2) → 1L-N1-benzyloxycarbonyl-O6-[2-benzyloxycarbonylamino-O6-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O5-[O2,O3-bis-(4-nitro-benzoyl)-O5-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N3,O4-carbonyl-2-deoxy-streptamine (68537-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) HCl, CH₂Cl₂, (ii) /BRN= 1068056/, Drierite, Hg(CN)2, (iii) Py, CHCl₃

2: AcOH / dioxane

3: Py / -10 °C

With pyridine; acetic acid; In 1,4-dioxane;

DOI:10.7164/antibiotics.31.863

Reference yield:

1L-N1-benzyloxycarbonyl-O6-(2-benzyloxycarbonylamino-O4,O6-cyclohexane-1,1-diyl-α-D-ribo-2,3-dideoxy-hexopyranosyl)-O5-[O2,O3-bis-(4-nitro-benzoyl)-O5-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N3,O4-carbonyl-2-deoxy-streptamine (68537-54-2) → 1L-N1-benzyloxycarbonyl-O6-[2-benzyloxycarbonylamino-O6-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O5-[O2,O3-bis-(4-nitro-benzoyl)-O5-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N3,O4-carbonyl-2-deoxy-streptamine (68537-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / dioxane

2: Py / -10 °C

With pyridine; acetic acid; In 1,4-dioxane;

DOI:10.7164/antibiotics.31.863

Reference yield:

methyl O2,O3-bis-(4-nitro-benzoyl)-O5-(toluene-4-sulfonyl)-ξ-D-ribofuranoside (68537-52-0,68537-59-7) → 1L-N1-benzyloxycarbonyl-O6-[2-benzyloxycarbonylamino-O6-(toluene-4-sulfonyl)-α-D-ribo-2,3-dideoxy-hexopyranosyl]-O5-[O2,O3-bis-(4-nitro-benzoyl)-O5-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N3,O4-carbonyl-2-deoxy-streptamine (68537-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) HCl, CH₂Cl₂, (ii) /BRN= 1068056/, Drierite, Hg(CN)2, (iii) Py, CHCl₃

2: AcOH / dioxane

3: Py / -10 °C

With pyridine; acetic acid; In 1,4-dioxane;

DOI:10.7164/antibiotics.31.863

upstream raw materials:

1L-N¹-benzyloxycarbonyl-O⁶-(2-benzyloxycarbonylamino-α-D-ribo-2,3-dideoxy-hexopyranosyl)-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine

p-toluenesulfonyl chloride

1L-N¹-benzyloxycarbonyl-O⁶-(2-benzyloxycarbonylamino-O⁴,O⁶-cyclohexane-1,1-diyl-α-D-ribo-2,3-dideoxy-hexopyranosyl)-N³,O⁴-carbonyl-2-deoxy-streptamine

1L-N¹-benzyloxycarbonyl-O⁶-(2-benzyloxycarbonylamino-O⁴,O⁶-cyclohexane-1,1-diyl-α-D-ribo-2,3-dideoxy-hexopyranosyl)-O⁵-[O²,O³-bis-(4-nitro-benzoyl)-O⁵-(toluene-4-sulfonyl)-β-D-xylofuranosyl]-N³,O⁴-carbonyl-2-deoxy-streptamine