N⁶-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate

Base Information

• Chemical Name: N⁶-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate
• CAS No.: 143415-95-6
• Molecular Formula: C₆₇H₅₉FN₇O₁₃P
• Molecular Weight: 1220.22
• Mol file: 143415-95-6.mol

Synonyms:

Chemical Property of N⁶-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate

There total 2 articles about N⁶-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C70H62N9O13P → 1-benzoylimidazole (10364-94-0) + N6-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate (143415-95-6,143443-16-7)

Guidance literature:

With benzoyl fluoride; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

6-N-benzoyl-2'-deoxy-3'-O-dimethoxytrityladenosine (140712-79-4) + C38H48N3O7PSi (143415-92-3) → N6-benzoyl-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)adenosin-5'-yl 5'-O-(9-phenylxxanthen-9-yl)thymidin-3'-yl phosphorofluoridate (143415-95-6,143443-16-7)

Guidance literature:

With 1H-tetrazole; fluorosulfonylchloride; Yield given. Multistep reaction; 1) MeCN, 20 min, 2) MeCN, a) -50 deg C to r.t., b) r.t., 1 h;

upstream raw materials:

6-N-benzoyl-2'-deoxy-3'-O-dimethoxytrityladenosine

C₃₈H₄₈N₃O₇PSi