Benzenepropanol, a-cyclohexyl-

Base Information

• Chemical Name: Benzenepropanol, a-cyclohexyl-
• CAS No.: 125153-19-7
• Molecular Formula: C15H22O
• Molecular Weight: 218.339
• Mol file: 125153-19-7.mol

Synonyms:

Chemical Property of Benzenepropanol, a-cyclohexyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanol, a-cyclohexyl-

There total 12 articles about Benzenepropanol, a-cyclohexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

rac-1-cyclohexylethanol (1193-81-3) + benzyl alcohol (100-51-6,185532-71-2) → (1R,S)-1-cyclohexyl-3-phenyl-1-propanol (125153-19-7)

Guidance literature:

With C₂₃H₂₁MnN₂O₃P⁽¹⁺⁾*Br^(1-); potassium tert-butylate; In toluene; at 135 ℃; for 20h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1002/cssc.201801660

Reference yield: 62.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + cyclohexylmethyl alcohol (100-49-2) → (1R,S)-1-cyclohexyl-3-phenyl-1-propanol (125153-19-7)

Guidance literature:

With tetrafluoroboric acid diethyl ether; carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); at 100 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201609056

Reference yield: 60.0%

3-phenyl-propionaldehyde (104-53-0) → (1R,S)-1-cyclohexyl-3-phenyl-1-propanol (125153-19-7)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃;

DOI:10.1021/acs.orglett.9b01573

upstream raw materials:

3-phenyl-propionaldehyde

1-bromocyclohexane

1-phenyl-2-bromoethane

cyclohexanecarbaldehyde

Downstream raw materials:

1-cyclohexyl-1-mesyl-3-phenylpropane

1-cyclohexyl-3-phenyl-1-propyl phenyl sulfide

1-cyclohexyl-3-phenyl-1-propanone