Carsatrin, (R)-

Base Information

Chemical Name:Carsatrin, (R)-
CAS No.:125345-94-0
Molecular Formula:C₂₅H₂₆F₂N₆OS
Molecular Weight:496.584
Hs Code.:
UNII:8GTE24P9A9
Nikkaji Number:J1.238.681H

Synonyms:Carsatrin, (R)-;8GTE24P9A9;125345-94-0;UNII-8GTE24P9A9;SCHEMBL7289204;1-PIPERAZINEETHANOL, 4-(BIS(4-FLUOROPHENYL)METHYL)-.ALPHA.-((1H-PURIN-6-YLTHIO)METHYL)-, (.ALPHA.R)-;1-Piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-alpha-((1H-purin-6-ylthio)methyl)-, (alphaR)-

Suppliers and Price of Carsatrin, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Carsatrin, (R)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:496.18568697
Heavy Atom Count:35
Complexity:621

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC(CSC2=NC=NC3=C2NC=N3)O)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
Isomeric SMILES:C1CN(CCN1C[C@H](CSC2=NC=NC3=C2NC=N3)O)C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F

Technology Process of Carsatrin, (R)-

There total 3 articles about Carsatrin, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-(-)-(1,2-epoxypropyl)-4-[bis(4-fluorophenyl)methyl]piperazine

: 6112-76-1
6-mercaptopurine monohydrate

: 125345-94-0
(2R)-(-)-6-[1-[1-[bis(4-fluorophenyl)methyl]piperaz in-4-yl]-2-hydroxy-3-propanylthio]purine

Guidance literature:: In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 125345-94-0
(R)-(-)-4--α-<(1H-purin-6-ylthio)methyl>-1-piperazineethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / 50percent NaH / tetrahydrofuran / 48 h / Ambient temperature

2: 1.) 50percent NaH / 1.) DMF, 5 deg C, 20 min, 2.) DMF, RT, 72 h

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0957-4166(00)82104-7