{8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

Base Information

Chemical Name:{8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester
CAS No.:150115-66-5
Molecular Formula:C₂₉H₃₆N₄O₆
Molecular Weight:536.628
Hs Code.:

{8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

Synonyms:

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Chemical Property of {8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

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Technology Process of {8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

There total 1 articles about {8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 149195-65-3
(8-Aminomethyl-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetic acid methyl ester

: 150115-66-5
{8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min;
DOI:10.1016/S0040-4020(01)90218-2

Reference yield:

: 150115-66-5
{8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

: {8-[((S)-2-Amino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(01)90218-2

Reference yield:

: 150115-66-5
{8-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-methyl]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid methyl ester

: 150115-70-1
C₄₈H₆₃N₉O₈

Guidance literature:: Multi-step reaction with 7 steps

1: HCl(g) / CH₂Cl₂ / 1 h / 0 °C

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min

3: HCl(g) / CH₂Cl₂ / 1 h / 0 °C

4: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min

5: HCl(g) / CH₂Cl₂ / 1 h / 0 °C

6: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min

7: 0.46 g / hydrazine / methanol / 30 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrazine; isobutyl chloroformate; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)90218-2