Multi-step reaction with 7 steps
1: HCl(g) / CH2Cl2 / 1 h / 0 °C
2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min
3: HCl(g) / CH2Cl2 / 1 h / 0 °C
4: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min
5: HCl(g) / CH2Cl2 / 1 h / 0 °C
6: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 20 min
7: 0.46 g / hydrazine / methanol / 30 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; hydrazine; isobutyl chloroformate;
In
methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)90218-2