Chemical Property of Tyrocidine A
Chemical Property:
- PSA：414.64000
- LogP:4.61050
- XLogP3:2.8
- Hydrogen Bond Donor Count:13
- Hydrogen Bond Acceptor Count:14
- Rotatable Bond Count:19
- Exact Mass:1269.65462988
- Heavy Atom Count:92
- Complexity:2510
- Purity/Quality:
-
99%, *data from raw suppliers
Tyrocidine Complex ≥95% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
- Isomeric SMILES:CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
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Uses
Tyrocidine is a family of eight cationic cyclic decapeptides produced by Bacillus brevis, first reported by Dubos in 1941. Tyrocidines exhibit broad antibiotic activity against Gram positive and negative bacteria and are the major component of the tyrothricin complex which is used for treatment of topical infections. Although the mechanism of action of tyrocidines is not fully understood, they are known to act by disturbing lipid bilayers of the bacterial cell membrane.
