[(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

Base Information

Chemical Name:[(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester
CAS No.:105878-76-0
Molecular Formula:C₃₄H₅₂O₇Si
Molecular Weight:600.868
Hs Code.:

[(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

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Chemical Property of [(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

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Technology Process of [(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

There total 5 articles about [(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 105878-75-9
(S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-3,3-dimethyl-tetrahydro-pyran-2-one

: 105878-76-0
[(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(00)99027-0

Reference yield:

: (S)-3,5,6-Trihydroxy-2,2-dimethyl-hexanoic acid ethyl ester

: 105878-76-0
[(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Imidazole / dimethylformamide

2: CSA / benzene / 72percent overall yield from INO 660

3: PPTS / CH₂Cl₂

4: LDA / tetrahydrofuran / -78 °C

With 1H-imidazole; camphor-10-sulfonic acid; pyridinium p-toluenesulfonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)99027-0

Reference yield:

: 103577-08-8,103602-41-1,105929-10-0
4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2,2-dimethyl-butyric acid ethyl ester

: 105878-76-0
[(2S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-ethoxy-ethoxy)-2-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / methanol

2: Imidazole / dimethylformamide

3: CSA / benzene / 72percent overall yield from INO 660

4: PPTS / CH₂Cl₂

5: LDA / tetrahydrofuran / -78 °C

With 1H-imidazole; camphor-10-sulfonic acid; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)99027-0