2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Base Information

Chemical Name:2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester
CAS No.:75091-03-1
Molecular Formula:C₂₈H₂₆Cl₂N₄O₄
Molecular Weight:553.445
Hs Code.:

2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Synonyms:

Suppliers and Price of 2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

There total 5 articles about 2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54527-68-3
2-chloroethyl acetoacetate

: 75091-03-1
2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine, AcOH / benzene / 9.5 h / Heating

2: 3 h / 100 °C

3: 92.7 percent / Et₃N / ethanol / 56 h / Heating

4: 100 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

5: 1.) NH₂OH*H₂O, AcONa, 2.) Ac₂O / 1.) AcOH, RT, 0.5 h, 2.) a) RT, 0.5 h, b) reflux, 1 h

With piperidine; hydrogenchloride; hydroxylamine; sodium acetate; acetic anhydride; acetic acid; triethylamine; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.912

Reference yield:

: 75206-24-5,75206-25-6
2-[1-(2-Cyano-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-chloro-ethyl ester

: 75091-03-1
2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 3 h / 100 °C

2: 92.7 percent / Et₃N / ethanol / 56 h / Heating

3: 100 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

4: 1.) NH₂OH*H₂O, AcONa, 2.) Ac₂O / 1.) AcOH, RT, 0.5 h, 2.) a) RT, 0.5 h, b) reflux, 1 h

With hydrogenchloride; hydroxylamine; sodium acetate; acetic anhydride; triethylamine; In ethanol; acetone;
DOI:10.1248/cpb.40.912

Reference yield:

: 75206-34-7
4-(2-Cyano-phenyl)-2-diethoxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-chloro-ethyl) ester 3-ethyl ester

: 75091-03-1
2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92.7 percent / Et₃N / ethanol / 56 h / Heating

2: 100 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

3: 1.) NH₂OH*H₂O, AcONa, 2.) Ac₂O / 1.) AcOH, RT, 0.5 h, 2.) a) RT, 0.5 h, b) reflux, 1 h

With hydrogenchloride; hydroxylamine; sodium acetate; acetic anhydride; triethylamine; In ethanol; acetone;
DOI:10.1248/cpb.40.912