sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Base Information

Chemical Name:sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate
CAS No.:105628-89-5
Molecular Formula:C₂₃H₂₄N₅O₁₀*Na
Molecular Weight:553.461
Hs Code.:

sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

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Chemical Property of sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

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Technology Process of sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

There total 3 articles about sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 106962-27-0,107034-08-2,128899-32-1
2-((S)-4-{(R)-2-[(4-Ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-3-oxo-isoxazolidin-2-yl)-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester

: 105628-89-5,107034-04-8,107079-02-7
sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Guidance literature:: With disodium hydrogenphosphate; sodium dihydrogenphosphate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1248/cpb.38.116

Reference yield:

: 63422-71-9
(R)-α-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]benzeneacetic acid

: 105628-89-5,107034-04-8,107079-02-7
sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / HOBT, DCC / dimethylformamide / 0.67 h / Ambient temperature

2: 80 percent / aq. NaH₂PO₄-Na₂HPO₄, H₂ / 5percent palladium-charcoal / tetrahydrofuran / 0.33 h / 0 °C

With disodium hydrogenphosphate; sodium dihydrogenphosphate; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.116

Reference yield:

: 106962-17-8,106962-18-9,115441-24-2
benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

: 105628-89-5,107034-04-8,107079-02-7
sodium 2-<(4S)-<2-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-(2R)-2-phenylacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / HOBT, DCC / dimethylformamide / 0.67 h / Ambient temperature

2: 80 percent / aq. NaH₂PO₄-Na₂HPO₄, H₂ / 5percent palladium-charcoal / tetrahydrofuran / 0.33 h / 0 °C

With disodium hydrogenphosphate; sodium dihydrogenphosphate; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.116