1,3,2-Benzodiazaphosphorine-2(1H)-carbothioamide, 3-(2-chloroethyl)-3,4-dihydro-1-methyl-4-oxo-N-phenyl-, 2-oxide

Base Information

Chemical Name:1,3,2-Benzodiazaphosphorine-2(1H)-carbothioamide, 3-(2-chloroethyl)-3,4-dihydro-1-methyl-4-oxo-N-phenyl-, 2-oxide
CAS No.:125405-41-6
Molecular Formula:C17H17ClN3O2PS
Molecular Weight:393.834
Hs Code.:
Mol file:125405-41-6.mol

Synonyms:

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Chemical Property of 1,3,2-Benzodiazaphosphorine-2(1H)-carbothioamide, 3-(2-chloroethyl)-3,4-dihydro-1-methyl-4-oxo-N-phenyl-, 2-oxide

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Technology Process of 1,3,2-Benzodiazaphosphorine-2(1H)-carbothioamide, 3-(2-chloroethyl)-3,4-dihydro-1-methyl-4-oxo-N-phenyl-, 2-oxide

There total 3 articles about 1,3,2-Benzodiazaphosphorine-2(1H)-carbothioamide, 3-(2-chloroethyl)-3,4-dihydro-1-methyl-4-oxo-N-phenyl-, 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 103-72-0
phenyl isothiocyanate

: 71476-09-0
5,6-Benzo-1-methyl-3-(2-chlorethyl)-2-hydro-2-oxo-1,3,2λ⁴-diazaphosphorinan-4-on

: 125405-41-6
1-methyl-3-(2-chloroethyl)-2-(N-phenylthiocarbamoyl)-4-oxo-1,2,3,4-tetrahydro-1,3,2-benzodiazaphosphorine 2-oxide

Guidance literature:: With triethylamine; In benzene; at 60 ℃; for 5h;
DOI:10.1055/s-1989-27336

Reference yield:

: 10328-92-4
N-Methylisatoic anhydride

: 125405-41-6
1-methyl-3-(2-chloroethyl)-2-(N-phenylthiocarbamoyl)-4-oxo-1,2,3,4-tetrahydro-1,3,2-benzodiazaphosphorine 2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / Et₃N / dioxane; H₂O / 3 h / 50 °C

2: 1.) PCl₃, 2.) 5percent aq. NaHCO₃ / 1.) benzene, reflux, 5 h, 2.) 0 deg C

3: 61 percent / Et₃N / benzene / 5 h / 60 °C

With sodium hydrogencarbonate; triethylamine; phosphorus trichloride; In 1,4-dioxane; water; benzene;
DOI:10.1055/s-1989-27336

Reference yield:

: 3417-04-7
[2-(4,5-dihydro-oxazol-2-yl)-phenyl]-methyl-amine

: 125405-41-6
1-methyl-3-(2-chloroethyl)-2-(N-phenylthiocarbamoyl)-4-oxo-1,2,3,4-tetrahydro-1,3,2-benzodiazaphosphorine 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) PCl₃, 2.) 5percent aq. NaHCO₃ / 1.) benzene, reflux, 5 h, 2.) 0 deg C

2: 61 percent / Et₃N / benzene / 5 h / 60 °C

With sodium hydrogencarbonate; triethylamine; phosphorus trichloride; In benzene;
DOI:10.1055/s-1989-27336