(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

Base Information

Chemical Name:(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate
CAS No.:1075258-45-5
Molecular Formula:C₇H₆O₂*C₂₄H₂₆FN₅O₄
Molecular Weight:589.623
Hs Code.:

(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

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Chemical Property of (6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

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Technology Process of (6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

There total 3 articles about (6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075258-42-2
(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one

: 65-85-0,8013-63-6
benzoic acid

: 1075258-45-5
(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

Guidance literature:: In methanol;

Reference yield:

: 443955-90-6
2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde

: 1075258-45-5
(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; acetic acid / methanol / 0.67 h / 20 °C

1.2: (polystyrylmethyl)trimethylammonium cyanoborohydride / 20 °C

2.1: methanol

With sodium acetate; acetic acid; In methanol;

Reference yield:

: (6R)-6-[(4-amino-1-piperidinyl)methyl]-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one dihydrochloride

: 1075258-45-5
(6R)-6-({4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-3-fluoro-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de]-1,5-naphthyridin-8-one benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; acetic acid / methanol / 0.67 h / 20 °C

1.2: (polystyrylmethyl)trimethylammonium cyanoborohydride / 20 °C

2.1: methanol

With sodium acetate; acetic acid; In methanol;