(R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Base Information

Chemical Name:(R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester
CAS No.:203786-48-5
Molecular Formula:C₅₃H₅₈N₆O₁₀
Molecular Weight:939.078
Hs Code.:

(R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

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Chemical Property of (R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

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Technology Process of (R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

There total 11 articles about (R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₈H₆₈N₆O₁₂

: 203786-48-5
(R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Guidance literature:: With diethylamine; In acetonitrile; Ambient temperature;
DOI:10.1055/s-1998-1606

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 203786-48-5
(R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 24 h

2: Et₂NH / acetonitrile / Ambient temperature

With diethylamine; In acetone; acetonitrile;
DOI:10.1055/s-1998-1606

Reference yield:

: (R)-Tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

: 203786-48-5
(R)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-propionyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 3-benzhydryl ester 1-benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / AgCN / benzene / 0.17 h / 60 - 80 °C

2: 95 percent / TFA, PhOH / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 64 percent / DCC, HOBT / tetrahydrofuran / 4 h / 0 °C

4: Et₂NH / acetonitrile / 0.83 h / Ambient temperature

5: Et₃N / CH₂Cl₂

6: CH₂Cl₂ / 5 h / -10 - 0 °C

7: TFA / CH₂Cl₂ / 1 h / 0 °C

8: NBS, H₂O / tetrahydrofuran

9: acetone / 24 h

10: Et₂NH / acetonitrile / Ambient temperature

With N-Bromosuccinimide; silver cyanide; water; benzotriazol-1-ol; diethylamine; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; phenol; In tetrahydrofuran; dichloromethane; acetone; acetonitrile; benzene;
DOI:10.1055/s-1998-1606