Technology Process of C16H21(2)HO2
There total 9 articles about C16H21(2)HO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 93 percent / LiAlH4 / diethyl ether / 30 h / Heating
2: pyridine / 4 h / -30 °C
3: KOH / methanol; H2O / 6 h / Heating
4: 4.5 g / pyridine; benzene / 72 h / Ambient temperature
5: 93 percent / 1,8-Diazabicyclo<5.4.0>undec-7-ene / dioxane / 3 h / Heating
6: 1.8 g / KOH / methanol; H2O
7: 1.8 g / NaH / tetrahydrofuran / Heating
8: 99 percent / 1) BF3*Et2O, LiAlD4 ; 2) H2O2, NaOH / 1) THF, 2 h, 20 deg C; 2) 60 deg C, 2 h
9: Pyridinium chlorochromate / CH2Cl2 / 1 h
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; lithium aluminium deuteride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; dichloromethane; water; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: pyridine / 4 h / -30 °C
2: KOH / methanol; H2O / 6 h / Heating
3: 4.5 g / pyridine; benzene / 72 h / Ambient temperature
4: 93 percent / 1,8-Diazabicyclo<5.4.0>undec-7-ene / dioxane / 3 h / Heating
5: 1.8 g / KOH / methanol; H2O
6: 1.8 g / NaH / tetrahydrofuran / Heating
7: 99 percent / 1) BF3*Et2O, LiAlD4 ; 2) H2O2, NaOH / 1) THF, 2 h, 20 deg C; 2) 60 deg C, 2 h
8: Pyridinium chlorochromate / CH2Cl2 / 1 h
With
potassium hydroxide; sodium hydroxide; lithium aluminium deuteride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.8 g / NaH / tetrahydrofuran / Heating
2: 99 percent / 1) BF3*Et2O, LiAlD4 ; 2) H2O2, NaOH / 1) THF, 2 h, 20 deg C; 2) 60 deg C, 2 h
3: Pyridinium chlorochromate / CH2Cl2 / 1 h
With
sodium hydroxide; lithium aluminium deuteride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;