(1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane

Base Information

Chemical Name:(1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane
CAS No.:77704-42-8
Molecular Formula:C₁₆H₂₂O₃S
Molecular Weight:294.415
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

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Technology Process of (1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane

There total 12 articles about (1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77704-70-2
(-)-(R)-N-<(Furan-2-yl)methyl>-N-(2-hyydroxy-1-phenylethyl)-3-methylbut-2-enamid

: 77704-42-8
(1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 12 steps

1: toluene / 50 h / Heating

2: H₂ / Pd/C

3: 78 percent / Na, liq. ammonia / tetrahydrofuran / -78 °C

4: sodium nitrite, acetic acid, acetic anhydride

5: KOH

6: 2N hydrochloric acid / pH= 7

7: CBr₄, PPh₃ / tetrahydrofuran / 0 °C

8: Ph₃SnH, AIBN / benzene / Heating

9: LiAlH₄ / diethyl ether / 0 °C

10: pyridine / 0 °C

11: ethanol / Ambient temperature

12: MCPBA / CH₂Cl₂ / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; triphenylstannane; ammonia; hydrogen; sodium; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene; benzene;
DOI:10.1246/cl.1981.29

Reference yield:

: 77704-39-3,77788-12-6
(1S,5S,7R)-3-((R)-2-Hydroxy-1-phenyl-ethyl)-6,6-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one

: 77704-42-8
(1S,2S,4R)-2-Benzenesulfonylmethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 11 steps

1: H₂ / Pd/C

2: 78 percent / Na, liq. ammonia / tetrahydrofuran / -78 °C

3: sodium nitrite, acetic acid, acetic anhydride

4: KOH

5: 2N hydrochloric acid / pH= 7

6: CBr₄, PPh₃ / tetrahydrofuran / 0 °C

7: Ph₃SnH, AIBN / benzene / Heating

8: LiAlH₄ / diethyl ether / 0 °C

9: pyridine / 0 °C

10: ethanol / Ambient temperature

11: MCPBA / CH₂Cl₂ / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; triphenylstannane; ammonia; hydrogen; sodium; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1246/cl.1981.29