Technology Process of 1-[(E)-(5R,6S,14R)-16-Benzyloxy-5-(2-methoxy-ethoxymethoxy)-2,6,10,14-tetramethyl-hexadeca-2,10-diene-8-sulfonyl]-4-methyl-benzene
There total 14 articles about 1-[(E)-(5R,6S,14R)-16-Benzyloxy-5-(2-methoxy-ethoxymethoxy)-2,6,10,14-tetramethyl-hexadeca-2,10-diene-8-sulfonyl]-4-methyl-benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 80 percent / Na2CO3 / methanol
2: 10 molpercent CuBr / tetrahydrofuran / -20 °C
3: LAH
4: C5H5N
5: i-PrNEt
6: 80percent AcOH
7: C5H5N
8: LiI / dimethylformamide / 42 h / Ambient temperature
9: 1.) n-BuLi / 1.) THF, -20 deg C, 2.) -78 deg C then 0 deg C
With
pyridine; lithium aluminium tetrahydride; n-butyllithium; i-PrNEt; sodium carbonate; acetic acid; copper(I) bromide; lithium iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)87623-6
- Guidance literature:
-
Multi-step reaction with 12 steps
1: Pb(OAc)4, Cu(OAc)2 / benzene / Heating
2: 10percent KOH
3: 75 percent / I2 / acetonitrile / 72 h / -20 °C
4: 80 percent / Na2CO3 / methanol
5: 10 molpercent CuBr / tetrahydrofuran / -20 °C
6: LAH
7: C5H5N
8: i-PrNEt
9: 80percent AcOH
10: C5H5N
11: LiI / dimethylformamide / 42 h / Ambient temperature
12: 1.) n-BuLi / 1.) THF, -20 deg C, 2.) -78 deg C then 0 deg C
With
pyridine; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; copper diacetate; i-PrNEt; iodine; sodium carbonate; acetic acid; copper(I) bromide; lithium iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)87623-6
- Guidance literature:
-
Multi-step reaction with 14 steps
1: O3
2: Jones oxidation
3: Pb(OAc)4, Cu(OAc)2 / benzene / Heating
4: 10percent KOH
5: 75 percent / I2 / acetonitrile / 72 h / -20 °C
6: 80 percent / Na2CO3 / methanol
7: 10 molpercent CuBr / tetrahydrofuran / -20 °C
8: LAH
9: C5H5N
10: i-PrNEt
11: 80percent AcOH
12: C5H5N
13: LiI / dimethylformamide / 42 h / Ambient temperature
14: 1.) n-BuLi / 1.) THF, -20 deg C, 2.) -78 deg C then 0 deg C
With
pyridine; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; copper diacetate; i-PrNEt; iodine; sodium carbonate; ozone; acetic acid; copper(I) bromide; lithium iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)87623-6
