Technology Process of (4R,5R)-Dibenzyl 1,3,2-Dioxathiolane-4,5-dicarboxylate 2,2-Dioxide
There total 1 articles about (4R,5R)-Dibenzyl 1,3,2-Dioxathiolane-4,5-dicarboxylate 2,2-Dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ruthenium trichloride; sodium periodate; thionyl chloride; triethylamine;
Yield given. Multistep reaction;
1) CH2Cl2, room temp., 1 h, 2) MeCN, H2O, room temp., 60 min.;
DOI:10.1021/jo00304a024
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) NaN3, 2) 20 percent aq. H2SO4 / 1) acetone, H2O, room temp., 1 h, 2) Et2O, room temp., 16 h
2: 82 percent / i-Pr2NEt, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 18 h / Ambient temperature
3: 89 percent / PPh3 / tetrahydrofuran; H2O / 18 h / 60 °C
4: 1) Me3SiCl, Et3N, 2) t-BuMgCl / 1) Et2O, 0 deg C, 1 h, 2) Et2O, room temp., 18 h
With
dmap; chloro-trimethyl-silane; sodium azide; sulfuric acid; tert-butylmagnesium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00304a024
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) NaN3, 2) 20 percent aq. H2SO4 / 1) acetone, H2O, room temp., 1 h, 2) Et2O, room temp., 16 h
2: 82 percent / i-Pr2NEt, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 18 h / Ambient temperature
3: 89 percent / PPh3 / tetrahydrofuran; H2O / 18 h / 60 °C
With
dmap; sodium azide; sulfuric acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00304a024