(±)-forskolin

Base Information

• Chemical Name: (±)-forskolin
• CAS No.: 132620-07-6
• Molecular Formula: C₂₂H₃₄O₇
• Molecular Weight: 410.508

Synonyms:

Chemical Property of (±)-forskolin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-forskolin

There total 72 articles about (±)-forskolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic anhydride (108-24-7) + (+/-)-desacetyl forskolin (64657-20-1,66428-84-0,114298-68-9,119618-16-5,132620-06-5,132620-08-7) → (±)-forskolin (66428-89-5,66575-29-9,112420-42-5,119618-17-6,132620-07-6,64657-11-0)

Guidance literature:

With pyridine; at 0 ℃; for 20h;

DOI:10.1002/anie.201706809

Reference yield:

dimethyl 2,2-dimethylglutarate (13051-32-6) → (±)-forskolin (66428-89-5,66575-29-9,112420-42-5,119618-17-6,132620-07-6,64657-11-0)

Guidance literature:

Multi-step reaction with 35 steps

3: tetrahydrofuran / 0.5 h / -78 °C

4: H₂, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C

5: DMAP / CH₂Cl₂ / 2 h / Heating

6: 35 percent / Pd(PPh₃)4, Et₃N / tetrahydrofuran / 5 h / Heating

7: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube

8: 90 percent / OsO₄, Me₃NO, pyridine / 2-methyl-propan-2-ol; H₂O / 18 h / Heating

9: 81 percent / SO₃-pyridine, Et₃N / 20 h / 20 °C

10: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C

11: 87 percent / t-BuNH₃-BH₃ / methanol / 21 h / 23 °C

12: 95 percent / TsOH / benzene / 1 h / 23 °C

13: 94 percent / MCPBA / CH₂Cl₂ / 0.5 h / -25 °C

14: 68 percent / CaCO₃ / toluene / 70 h / Heating

15: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C

16: 89 percent / LiAlH₄ / diethyl ether / 1 h / Heating

17: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating

18: 83 percent / 1.) OsO₄, 2.) H₂S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h

19: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C

20: 95 percent / TsOH / CHCl₃; methanol / 0.67 h / 20 °C

21: 96 percent / pyridine / 2 h / 20 °C

22: 95 percent / TsOH / 0.25 h / 20 °C

23: 95 percent / LiAlH₄ / diethyl ether / 0.17 h / 0 °C

24: 78 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 16 h / 23 °C

25: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C

26: 79 percent / MnO₂ / benzene / 3 h / 23 °C

27: 93 percent / diethyl ether / 0.25 h / -78 °C

28: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min

29: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH₂Cl₂, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min

30: 97 percent / n-Bu₄NF / tetrahydrofuran / 5 h / 23 °C

31: 89 percent / n-Bu₃P / tetrahydrofuran / 0.5 h / 23 °C

32: 84 percent / 30percent H₂O₂ / CH₂Cl₂ / 20 h / 18 °C

33: 96 percent / 1.) DDQ, 2.) K₂CO₃ / 1.) CH₂Cl₂ - H₂O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min

34: 77 percent / aq. HClO₄; tetrahydrofuran / 60 h / 23 °C

35: 85 percent / pyridine / 9 h / 0 °C

With pyridine; quinoline; dmap; manganese(IV) oxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Phenylselenyl chloride; sodium hydrogen telluride; pyridine-SO₃ complex; trimethylamine-N-oxide; tributylphosphine; Ra-Ni(W-2); N-tert-butylaminoborane; hydrogen sulfide; lithium methanolate; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium carbonate; Lindlar's catalyst; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; perchloric acid; diethyl ether; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/ja00219a058

Reference yield:

4,4-dimethyl-5-(tetrahydro-2H-pyran-2-yloxy)pentanal (141424-11-5) → (±)-forskolin (66428-89-5,66575-29-9,112420-42-5,119618-17-6,132620-07-6,64657-11-0)

Guidance literature:

Multi-step reaction with 34 steps

2: tetrahydrofuran / 0.5 h / -78 °C

3: H₂, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C

4: DMAP / CH₂Cl₂ / 2 h / Heating

5: 35 percent / Pd(PPh₃)4, Et₃N / tetrahydrofuran / 5 h / Heating

6: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube

7: 90 percent / OsO₄, Me₃NO, pyridine / 2-methyl-propan-2-ol; H₂O / 18 h / Heating

8: 81 percent / SO₃-pyridine, Et₃N / 20 h / 20 °C

9: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C

10: 87 percent / t-BuNH₃-BH₃ / methanol / 21 h / 23 °C

11: 95 percent / TsOH / benzene / 1 h / 23 °C

12: 94 percent / MCPBA / CH₂Cl₂ / 0.5 h / -25 °C

13: 68 percent / CaCO₃ / toluene / 70 h / Heating

14: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C

15: 89 percent / LiAlH₄ / diethyl ether / 1 h / Heating

16: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating

17: 83 percent / 1.) OsO₄, 2.) H₂S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h

18: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C

19: 95 percent / TsOH / CHCl₃; methanol / 0.67 h / 20 °C

20: 96 percent / pyridine / 2 h / 20 °C

21: 95 percent / TsOH / 0.25 h / 20 °C

22: 95 percent / LiAlH₄ / diethyl ether / 0.17 h / 0 °C

23: 78 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 16 h / 23 °C

24: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C

25: 79 percent / MnO₂ / benzene / 3 h / 23 °C

26: 93 percent / diethyl ether / 0.25 h / -78 °C

27: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min

28: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH₂Cl₂, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min

29: 97 percent / n-Bu₄NF / tetrahydrofuran / 5 h / 23 °C

30: 89 percent / n-Bu₃P / tetrahydrofuran / 0.5 h / 23 °C

31: 84 percent / 30percent H₂O₂ / CH₂Cl₂ / 20 h / 18 °C

32: 96 percent / 1.) DDQ, 2.) K₂CO₃ / 1.) CH₂Cl₂ - H₂O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min

33: 77 percent / aq. HClO₄; tetrahydrofuran / 60 h / 23 °C

34: 85 percent / pyridine / 9 h / 0 °C

With pyridine; quinoline; dmap; manganese(IV) oxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Phenylselenyl chloride; sodium hydrogen telluride; pyridine-SO₃ complex; trimethylamine-N-oxide; tributylphosphine; Ra-Ni(W-2); N-tert-butylaminoborane; hydrogen sulfide; lithium methanolate; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium carbonate; Lindlar's catalyst; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; perchloric acid; diethyl ether; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/ja00219a058

upstream raw materials:

acetic anhydride

1-Epi-7-deacetylcoleonol

1β-Benzoyloxy-1-deoxycoleonol

forskolin

Downstream raw materials:

7-deacetyl forskolin

C₂₂H₃₄O₇

forskolin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 132620-07-6 (±)-forskolin

Send

Send

Metric Ton KG G Pound L ML

Send

Send