2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile
CAS No.:1332485-10-5
Molecular Formula:C₃₀H₃₈N₂O₂
Molecular Weight:458.644
Hs Code.:

2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

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Suppliers and Price of 2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

There total 14 articles about 2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332489-08-3
2-(4-((3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

: 1332485-10-5
2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 12h;
DOI:10.1021/jm500431d

Reference yield:

: 1332488-70-6
2-(4-((3′R,9′S)-9′-(tert-butyldimethylsilyloxy)-2-iodo-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

: 1332485-10-5
2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium 10% on activated carbon; hydrogen / methanol / 12 h / 7500.75 Torr

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 25 °C

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm500431d

Reference yield:

: 1332487-12-3
2-(4-((R)-((S)-5-(tert-butyldimethylsilyloxy)-4-cyclopentenyl-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(hydroxy)methyl)phenyl)-2-methylpropanenitrile

: 1332485-10-5
2-(4-((3′R,9′S)-9′-hydroxy-4′-isopropyl-7′,7′-dimethyl-6′,7′,8′,9′-tetrahydro-3′H-spiro[cyclopentane-1,1′-furo[3,4-c]quinoline]-3′-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: Iodine monochloride / dichloromethane / 24 h / 25 °C

2: triethylamine; palladium 10% on activated carbon; hydrogen / methanol / 12 h / 7500.75 Torr

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 25 °C

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; Iodine monochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm500431d