cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride

Base Information

• Chemical Name: cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride
• CAS No.: 121318-00-1
• Molecular Formula: C₉H₁₁Br₂ClO
• Molecular Weight: 330.447
• Mol file: 121318-00-1.mol

Synonyms:

Chemical Property of cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride

There total 3 articles about cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid (121317-99-5) → cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride (121318-00-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1002/ps.2780440110

Reference yield:

4-formylcyclohexane carboxylic acid methyl ester (37942-76-0) → cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride (121318-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: P(C₆H₅)3 / CH₂Cl₂

2: 3.5 g / 48 percent aq. HBr / acetic acid / 4 h / Heating

3: (COCl)2; DMF / CH₂Cl₂ / 2 h / 25 °C

With oxalyl dichloride; hydrogen bromide; N,N-dimethyl-formamide; triphenylphosphine; In dichloromethane; acetic acid; 1: Condensation / 2: Hydrolysis / 3: Substitution;

DOI:10.1002/ps.2780440110

Reference yield:

Methyl cis-4-(2,2-dibromovinyl)cyclohexanecarboxylate (121317-97-3) → cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid chloride (121318-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.5 g / 48 percent aq. HBr / acetic acid / 4 h / Heating

2: (COCl)2; DMF / CH₂Cl₂ / 2 h / 25 °C

With oxalyl dichloride; hydrogen bromide; N,N-dimethyl-formamide; In dichloromethane; acetic acid; 1: Hydrolysis / 2: Substitution;

DOI:10.1002/ps.2780440110

upstream raw materials:

cis-4-(2,2-Dibromovinyl)cyclohexanecarboxylic acid

4-formylcyclohexane carboxylic acid methyl ester

Methyl cis-4-(2,2-dibromovinyl)cyclohexanecarboxylate

Downstream raw materials:

cis-1-[4-(2,2-Dibromovinyl)cyclohexyl]-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octane

3-tert-Butyloxetan-3-ylmethyl cis-4-(2,2-dibromovinyl)cyclohexylcarboxylate

Refernces