dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate

Base Information

Chemical Name:dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate
CAS No.:139704-87-3
Molecular Formula:C₂₇H₂₇F₂O₁₁P
Molecular Weight:596.475
Hs Code.:

dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<<bis(phenylmethoxy)phosphinyl>oxy>-1,4-benzodioxin-3,6-dicarboxylate

Synonyms:

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Chemical Property of dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate

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Technology Process of dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate

There total 4 articles about dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96283-92-0
methyl <(1R),1α,5β,6α>-5--8,8-dimethyl-7,9-dioxabicyclo<4.3.0>non-2-ene-3-carboxylate

: 139704-87-3,139891-16-0
dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium tert-butoxide / 1.) THF, RT, 30 min, 2.) HMPT, 45 deg C, 1 h

2: Dowex 50W-X₈ resin (H⁺ form) / methanol / 63 h / 60 - 65 °C

3: p-toluenesulfonic acid / benzene / 5.5 h / Heating

4: 1.) tetrazole, 2.) m-chloroperoxybenzoic acid (mCPBA) / 1.) THF, RT, 1.5 h, 2.) THF, CH₂Cl₂, from 0 deg C to RT, 40 min

With 1H-tetrazole; Dowex 50W-X₈ resin (H⁺ form); toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; In methanol; benzene;

Reference yield:

: 2-Difluoromethyl-2-((1R,5R,6R)-5,6-dihydroxy-3-methoxycarbonyl-cyclohex-3-enyloxy)-malonic acid dimethyl ester

: 139704-87-3,139891-16-0
dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / benzene / 5.5 h / Heating

2: 1.) tetrazole, 2.) m-chloroperoxybenzoic acid (mCPBA) / 1.) THF, RT, 1.5 h, 2.) THF, CH₂Cl₂, from 0 deg C to RT, 40 min

With 1H-tetrazole; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In benzene;

Reference yield:

: 139704-84-0
methyl <(1R),1α,5β,6α>-5-<2-bis(methoxycarbonyl)-1,1-difluoroethoxy>-8,8-dimethyl-7,9-dioxabicyclo<4.3.0>non-2-ene-3-carboxylate

: 139704-87-3,139891-16-0
dimethyl <(4aR),4aβ,8α,8aα>-2,3,4a,5,8,8a-hexahydro-2-oxo-3-(difluoromethyl)-8-<oxy>-1,4-benzodioxin-3,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Dowex 50W-X₈ resin (H⁺ form) / methanol / 63 h / 60 - 65 °C

2: p-toluenesulfonic acid / benzene / 5.5 h / Heating

3: 1.) tetrazole, 2.) m-chloroperoxybenzoic acid (mCPBA) / 1.) THF, RT, 1.5 h, 2.) THF, CH₂Cl₂, from 0 deg C to RT, 40 min

With 1H-tetrazole; Dowex 50W-X₈ resin (H⁺ form); toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; benzene;