o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide

Base Information

• Chemical Name: o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide
• CAS No.: 82057-58-7
• Molecular Formula: C₅₂H₇₆N₁₂O₁₄S₂
• Molecular Weight: 1157.38
• Mol file: 82057-58-7.mol

Synonyms:

Chemical Property of o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide

There total 3 articles about o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-((S)-3-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-4-carbamoyl-butyrylamino]-3-carbamoyl-propionylamino}-4-{(S)-2-[(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-butylsulfanyl)-propionic acid (30905-50-1) + (S)-3-(4-Ethyl-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid 2,4,5-trichloro-phenyl ester (84796-43-0) → o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide (82057-58-7)

Guidance literature:

With 1-ethyl-piperidine; In N,N-dimethyl-formamide; for 120h; Ambient temperature;

Reference yield:

(S)-3-(4-Ethyl-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid; compound with dicyclohexyl-amine (84796-37-2) → o-nitrobenzenesulfenyl-p-ethylphenylalanyl-isoleucyl-glutaminyl-asparaginyl-S-(β-carboxyethyl)homocysteinyl-prolyl-leucyl-glycine amide (82057-58-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 83 percent / N-ethylpiperidine / dimethylformamide / 120 h / Ambient temperature

With 1-ethyl-piperidine; In N,N-dimethyl-formamide;

Reference yield:

(R)-3-(4-Ethyl-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid; compound with dicyclohexyl-amine (96958-95-1) + 3-((S)-3-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-4-carbamoyl-butyrylamino]-3-carbamoyl-propionylamino}-4-{(R)-2-[(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-butylsulfanyl)-propionic acid (30905-50-1) → C52H76N12O14S2 (82057-58-7,89740-47-6,113981-97-8)

Guidance literature:

With sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction;

DOI:10.1135/cccc19850132

upstream raw materials:

(R)-3-(4-Ethyl-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid; compound with dicyclohexyl-amine

3-((S)-3-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-4-carbamoyl-butyrylamino]-3-carbamoyl-propionylamino}-4-{(R)-2-[(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-butylsulfanyl)-propionic acid

3-((S)-3-{(S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-4-carbamoyl-butyrylamino]-3-carbamoyl-propionylamino}-4-{(S)-2-[(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-butylsulfanyl)-propionic acid

(S)-3-(4-Ethyl-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid 2,4,5-trichloro-phenyl ester

Downstream raw materials:

<2-p-Ethyl-D-phenylalanine>-deamino-6-carba-oxytocin Sulfoxide

<2-p-ethylphenylalanine>deamino-6-carba-oxytocin

<2-p-ethylphenylalanine>deamino-6-carba-oxytocin sulfoxide

<2-p-Ethyl-D-phenylalanine>-deamino-6-carba-oxytocin